An Evaluation of Long-Term Supplement Use on Biological Age and Metabolic Health Markers - The BioAge Trial

NCT07755943 | Recruiting

• 1 other identifier: BIO-2607
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate whether dietary supplement use (\> 1 year) is associated with differences in biological age relative to chronological age, as well as differences in metabolic health and functional fitness tests.

Conditions

Generally Healthy Adults Who Are Long-term Supplement Users

Outcome Measures

Primary Outcomes (1)

• Difference between biological and chronological age (years) calculated using a validated biological age calculator

  Differences will be compared to an NHANES cohort, where possible.

  Baseline single assessment for this observational study

Secondary Outcomes (14)

• Blood pressure (mm Hg)

  Baseline single assessment for this observational study

• Heart rate (beats per minute)

  Baseline single assessment for this observational study

• Body weight (kg)

  Baseline single assessment for this observational study

• Body mass index (kg/m2)

  Baseline single assessment for this observational study

• Waist-to-hip ratio

  Baseline single assessment for this observational study

Study Arms (1)

Generally healthy adults, 40 years of age and older, who are long-term (>1 year) supplement users

Participants will be long-term users (\>1 year) of the Sponsors supplement products

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

No intervention: observational cohort

Generally healthy adults, 40 years of age and older, who are long-term (>1 year) supplement users

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from a database of long-term Sponsor supplement users.

You may qualify if:

• Adults aged 40 years or older.
• Verified long-term Sponsor supplement use (\>1 year).
• Willing and able to provide informed consent and comply with study procedures.
• Able to fast overnight (\>8 hours) prior to the study visit.
• Willing and able to travel to the test site.
• Ambulatory and currently free of injury or other physical impairment that hinders mobility.
• Willing to use a personal smart phone or computer with internet access and active email address.
• Willing to adhere to all study procedures and sign forms providing informed consent to participate in the study and authorization to release relevant protected health information.

You may not qualify if:

• Current or recent (within 6 months) diagnosis of cancer except for non-melanoma skin cancer.
• Participant is pregnant or lactating.
• Participant has a pacemaker or other implanted electronic device.
• Any condition the study staff believes would interfere with the participant's ability to provide informed consent or comply with the study protocol, which might confound the interpretation of the study results or put the person at undue risk.

Sponsors & Collaborators

• Shaklee Corporation: lead
• Biofortis Clinical Research, Inc.: collaborator
• Nlumn LLC: collaborator

Study Sites (1)

Biofortis Clinical Research

Addison, Illinois, 60101, United States

RECRUITING

Related Publications (2)

• Jacques PF, Rogers G. A beneficial cardiometabolic health profile associated with dietary supplement use: A cross-sectional study. Int J Vitam Nutr Res. 2023 Feb;93(1):18-28. doi: 10.1024/0300-9831/a000701. Epub 2021 Mar 1.

  PMID: 33646010 RESULT

• Block G, Jensen CD, Norkus EP, Dalvi TB, Wong LG, McManus JF, Hudes ML. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study. Nutr J. 2007 Oct 24;6:30. doi: 10.1186/1475-2891-6-30.

  PMID: 17958896 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma and serum samples will be archived for possible future assessment of non-genetic indicators of metabolism.

Study Officials

• Erin Barrett, PhD

  Shaklee Corporation

  STUDY DIRECTOR

Central Study Contacts

Biofortis Research Clinical Director

CONTACT

(630) 617-2000; biofortisresearch@mxns.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 23, 2026
• First Posted: August 10, 2026
• Study Start: May 12, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)