Association Between Central Sensitization and the Root Mean Square of Successive Differences

NCT07755332 | Completed

• 1 other identifier: 2025-07-01
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to examine the relationship between central sensitization and resting RMSSD (Root Mean Square of Successive Differences) in individuals exhibiting prolonged sitting behavior, controlling for potential confounding factors such as age, gender, and body mass index; and to evaluate whether participants, grouped according to sitting durations, differed in terms of RMSSD, central sensitization, balance, and executive cognitive function.

Conditions

Healthy Participants

Keywords

postural balance; executive function; central sensitization

Outcome Measures

Primary Outcomes (3)

• Demographic Information Collection

  Demographic information of the participants was collected using a participant assessment form developed by the research team. The form collected information about age, height, weight, body mass index, gender, education level, and weekly sitting time.

  Baseline (Single Assessment)

• Assessment of Central Sensitization

  Central sensitivity was assessed using the Central Sensitivity Inventory. The scale ranges from 0 to 100, with higher scores indicating more severe symptoms.

  Baseline (Single Assessment)

• Assessment of Heart Rate Variability

  Heart rate variability measurements were recorded at rest for 5 minutes using a Polar H10 device, in accordance with the recommendations of the European Society of Cardiology. The device was secured to the lower sternal notch with a belt. The RMSSD (Root Mean Square of Successive Differences, ms) parameter was used as an indicator of vagal activity.

  Baseline (Single Assessment)

Secondary Outcomes (2)

• Assessment of Balance

  Baseline (Single Assessment)

• Assessment of cognitive/executive function

  Baseline (Single Assessment)

Study Arms (1)

Healthy participants

Individuals who were between the ages of 18-45, had at least 30 hours of sitting time per week, agreed to participate voluntarily, and met the inclusion criteria participated.

Other: No intervention

Interventions

No intervention OTHER

No intervention

Healthy participants

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of healthy young adults aged 18-45 years who spent at least 30 hours sitting per week.

You may qualify if:

• Age range: Between 18 and 45 years of age.
• Sitting time: Having at least 30 hours of sitting time per week.
• Voluntary participation: Voluntarily agreeing to participate in the study.
• Cognitive and sensory capacity: Having the cognitive, auditory, and visual capacity to understand the study procedures and perform the tasks.
• Physical fitness: Not having any physical condition that would prevent the use of the HRV measuring device.

You may not qualify if:

• Having any cardiovascular, neurological, or systemic disease that interferes with physical activity,
• Using medications that may affect the autonomic nervous system within the last month,
• Having a history of cognitive impairment,
• Having engaged in strenuous exercise or had a febrile illness within the last 24 hours,
• Having a clinically diagnosed central sensitization syndrome,
• Being pregnant

Sponsors & Collaborators

• Istanbul Demiroglu Bilim University: lead

Study Sites (1)

Demiroglu Bilim University

Istanbul, Silivri, 34570, Turkey (Türkiye)

Location

Study Officials

• Selin Akil Agdere, Asst. Prof.

  Istanbul Demiroglu Bilim University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst. Prof.

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 10, 2026
• Study Start: January 1, 2026
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)