Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls

NCT07754149 | Not Yet Recruiting DMC

• 1 other identifier: Amina Rizwan
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. While exercise is known to reduce symptoms, the optimal intensity of resistance training remains unclear. Using a randomized controlled trial design, participants are assigned to progressive or low-intensity training groups. PMS symptoms and quality of life are assessed over time. The study aims to determine whether higher exercise intensity leads to greater symptom reduction and improved overall well-being.

Conditions

Premenstrual Syndrome

Keywords

Premenstrual Syndrome, Resistance Training, Dose-Response, Adolescent Girls, Exercise Therapy, Quality of Life, Randomized Controlled Trial

Outcome Measures

Primary Outcomes (1)

• Premenstrual Symptoms Screening Tool (PSST)

  The primary outcome of this study is the severity of premenstrual syndrome symptoms, measured using the Premenstrual Symptoms Screening Tool (PSST). The PSST is a self-reported questionnaire used to assess physical, psychological, and behavioral symptoms related to PMS, including mood swings, irritability, anxiety, fatigue, bloating, breast tenderness, and difficulty concentrating. It also evaluates how these symptoms affect daily activities, school performance, and social relationships. Each item is scored on a 4-point Likert scale ranging from "none" to "severe." Higher scores indicate greater PMS severity..

  Assessments will be conducted at baseline, week 2, week 4, week 6, and at 3-month follow-up

Secondary Outcomes (1)

• Quality of Life (QoL)

  Quality of life will be assessed at baseline, immediately after the 6-week intervention, and at 3-month follow-up using the WHOQOL-BREF questionnaire.

Study Arms (2)

Progressive Resistance Training Group

EXPERIMENTAL

Participants allocated to this arm will receive a supervised 6-week progressive resistance training program performed three times per week on non-consecutive days. Each session will last 45-60 minutes.

Other: Progressive Resistance Training

Low-Intensity Resistance Training Group

ACTIVE COMPARATOR

Participants allocated to this arm will receive a supervised low-intensity resistance training program for six weeks. Sessions will be conducted three times per week, lasting 45-60 minutes each. Participants will perform the same standardized resistance exercises as the experimental group; however, exercise intensity will remain low throughout the intervention without progressive overload.

Other: Low-Intensity Resistance Training

Interventions

Progressive Resistance Training OTHER

A supervised progressive resistance training program delivered three sessions per week for six weeks. Exercise intensity is gradually increased using the Borg Rating of Perceived Exertion (RPE) scale. A warm up session will be done before resistance training exercise and Cool down for 5-10 minutes will be done exercise. Participants will follow the FITT prescription for their resistance exercises. Week 1-2 (DOSE 1) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25-30 reps. Volume: High. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: moderate. Bodyweight or dumbbells (RPE 12-14/20). Sets \& Reps: 2 sets of 20-25 repetitions. Volume: Moderate. Focus on mastering technique. Week 5-6(DOSE 3) Intensity: high. Dumbbells (RPE 15-16/20). Sets \& Reps: 2 sets of 15-20 repetitions. Volume: Low.

Progressive Resistance Training Group

Low-Intensity Resistance Training OTHER

Participants of this group will receive the same standardized exercises as the experimental group. Exercise intensity remains constant at low intensity throughout the intervention period without progressive increase. Before exercise the participants will perform warm up and after exercise they will perform cool down, same as the experimental group. The FITT protocol for this group is as following: Week 1-2 (DOSE1) Intensity: low Body weight. or Dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 15repetitions. Volume: Low. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 20 repetitions. Volume: Moderate. Focus on mastering technique Week 5-6(DOSE 3) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25 reps. Volume: High. Focus on mastering technique.

Low-Intensity Resistance Training Group

Eligibility Criteria

• Age: 11 Years - 19 Years
• Gender Eligibility Details: The study will include only adolescent participants who self-identify as female. This is because the target population consists of adolescent girls experiencing premenstrual syndrome (PMS), and the intervention is specifically designed for this group."
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Diagnosed with Premenstrual Syndrome (PMS) based on PSST screening tool.
• Not currently engaged in any structured resistance or exercise training program.
• Medically cleared to participate in moderate-intensity resistance training.
• Provided written informed consent for participation.

You may not qualify if:

• Current use of hormonal therapy or oral contraceptives.
• History of endocrine disorders (e.g., PCOS, thyroid dysfunction).
• Any musculoskeletal or cardiovascular condition limiting exercise participation.
• Ongoing psychiatric medication or diagnosed depression/anxiety disorder.
• Participation in a structured exercise or resistance training program within the last 3 months.
• Use of analgesics, anti-inflammatory, or hormonal medications during the study period.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Kid city high school , Kens college model town humak and community model town.

Islamabad, Federal, 051, Pakistan

Location

MeSH Terms

Conditions

Premenstrual Syndrome

Condition Hierarchy (Ancestors)

Menstruation Disturbances; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Rida Zafar, WHPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Dr.Rida Zafar, MSWHPT

CONTACT

03368753273; rida.zafar@riphah.edu.pk

Dr Summra Andleeb, MS-OMPT

CONTACT

0345-0617872; sammra.andleeb@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 10, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)