Intraoperative Laser Speckle Imaging Predicts Early Renal Function After Kidney Transplantation

NCT07753434 | Completed

• 1 other identifier: NO.2024-125
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to explore the predictive value of intraoperative laser speckle contrast imaging for early postoperative renal function in kidney transplant recipients. The core research question is: What is the efficacy of intraoperative laser speckle contrast imaging in predicting early postoperative renal function among kidney transplant patients? This study will enroll kidney transplant patients who undergo intraoperative laser speckle contrast imaging and collect relevant evaluation data. Last updated on February 27, 2025

Conditions

Postoperative Renal Function

Keywords

postoperative renal function; laser speckle contrast imaging

Outcome Measures

Primary Outcomes (1)

• Slow graft function (SGF)

  Within 7 days after renal transplantation

Secondary Outcomes (5)

• Postoperative Cr

  Within the first 7 postoperative days

• Postoperative BUN

  Within the first 7 postoperative days

• Postoperative UO

  Within the first 7 postoperative days

• Postoperative eGFR

  Within the first 7 postoperative days

• Hospital length of stay

  Up to 12 weeks

Interventions

laser speckle contrast imaging (LSCI) DEVICE

Before abdominal closure, renal microcirculation was assessed using the RFLSI-ZW laser speckle contrast imaging (LSCI) system (RWD Life Science) which was mounted on a portable stand. The device was positioned 15-30 cm above the transplanted kidney, with the speckle lens aligned to the graft surface. Automatic focusing was applied to optimize image clarity, and images of the upper pole of the kidney were captured within a 15 × 15 cm field of view. 60 seconds of microcirculation imaging and perfusion curves were recorded at the upper pole of the kidney after reperfusion and immediately prior to abdominal closure (Figure 1). Perfusion Index (PI) was calculated using the software of the RFLSI-ZW LSCI system, which was closely related to the product of mean erythrocyte flow velocity and concentration within the tissue.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent renal transplantation at our hospital between August 2024 and February 2025.

You may qualify if:

• Patients undergoing renal transplantation in our hospital.

You may not qualify if:

• Patients who need reoperation within 7 days after initial renal transplantation.
• Patients with acute rejection within 24 hours after operation.

Sponsors & Collaborators

• The Second Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China

Location

MeSH Terms

Interventions

Laser Speckle Contrast Imaging

Intervention Hierarchy (Ancestors)

Optical Imaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: August 1, 2026
• First Posted: August 7, 2026
• Study Start: August 1, 2024
• Primary Completion: February 1, 2025
• Study Completion: February 27, 2025
• Last Updated: August 7, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)