Photoactivated Disinfection Versus Laser Disinfection of Infected Sockets on the Success of Immediate Implant Placement

NCT07753044 | Completed

• 1 other identifier: 1044-03/2025
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Dental implantology offers reliable tooth replacement options, but infections in extraction sockets can compromise osseointegration. Conventional disinfection methods, such as chlorhexidine, often fail to completely eliminate pathogenic microorganisms and may impair tissue healing. Photoactivated disinfection (PAD) and laser disinfection have emerged as promising alternatives. PAD employs a light-activated photosensitizer to generate reactive oxygen species (ROS), effectively disrupting bacterial membranes while preserving host cell viability. In parallel, laser disinfection utilizes focused light energy to eliminate bacterial biofilms and contaminated tissue with minimal thermal damage. In this study, we specifically utilize the Er,Cr:YSGG laser, which operates at a water-absorbing wavelength to induce micro-explosions that mechanically disrupt biofilms and promote a cleaner socket environment for improved osseointegration. Aim of the study: To compare the effectiveness of photoactivated disinfection (PAD), Er,Cr:YSGG laser disinfection, and conventional disinfection with chlorhexidine in decontaminating infected extraction sockets prior to immediate implant placement, promoting bone healing, and improving the osseointegration and stability of immediate implants placed in infected extraction sockets.

Conditions

Infected Extraction Sockets

Outcome Measures

Primary Outcomes (3)

• implant stability

  Resonance Frequency Analysis (RFA) using Osstell ISQ: Implant Stability Quotient (ISQ) values will be recorded at 6 months after implant placement. Values from 1 to 100, the higher the ISQ, the higher the stability of the implant.

  6 months

• change in bone density

  Bone density assessment using radiographs immediately post-operative and at 6 months.

  baseline and 6 months

• change in marginal bone loss

  Marginal Bone Loss (MBL) assessment using radiographs immediately postoperative and at 6 months.

  baseline and 6 months

Secondary Outcomes (2)

• change in pain scores

  up to 7 days

• change in post-operative edema

  up to 7 days

Study Arms (3)

PAD

EXPERIMENTAL

Other: Photoactivated disinfection

Er,Cr:YSGG laser Group

EXPERIMENTAL

Other: Er,Cr:YSGG laser disinfection

Conventional group

ACTIVE COMPARATOR

Other: Chlorohexidine disinfection

Interventions

Photoactivated disinfection OTHER

Standard treatment + Toluidine blue + Light activation + Immediate implant placement

PAD

Er,Cr:YSGG laser disinfection OTHER

Standard treatment + Er,Cr:YSGG laser application + Immediate Implant placement

Er,Cr:YSGG laser Group

Chlorohexidine disinfection OTHER

Standard treatment + Chlorohexidine Irrigation + Immediate Implant placement

Conventional group

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients having posterior tooth/teeth indicated for extraction
• Patients must exhibit radiographic evidence of infection, defined as chronic periapical pathology (radiolucency)
• The extraction site should have intact surrounding alveolar bone
• There must be at least 2 mm of sound bone beyond the root apex
• Patients must be in overall good health and free from uncontrolled systemic conditions

You may not qualify if:

• History of radiation therapy in the head and neck region
• Pregnant or lactating women
• Patients on long-term antibiotic therapy, as it could influence the outcomes
• Heavy Smoking: More than 10-15 cigarettes per day.
• Significant bruxism or parafunctional habits affecting implant stability.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt

Alexandria, Azarita, 00203, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 4, 2026
• First Posted: August 7, 2026
• Study Start: June 10, 2025
• Primary Completion: February 3, 2026
• Study Completion: February 3, 2026
• Last Updated: August 7, 2026

Record last verified: 2026-08

Locations

EG (1)