Network Modeling in Knee Osteoarthritis

NCT07746284 | Enrolling By Invitation DMC

• 2 other identifiers: STUDY00000740R01AT013603
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of cMSKP and guide personalized primary, secondary and tertiary prevention strategies. Our secondary objective is to understand how inter-relationships between physiological, biomechanical and psychosocial factors change over time and impact the experience of living with chronic pain.

Conditions

Chronic Musculoskeletal Pain

Outcome Measures

Primary Outcomes (1)

• Symptom network

  We will construct time varying networks for each patient based on longitudinal variables describing multiple domains: psychosocial, biomechanical and physiological. Change in network topology will be used as the primary outcome measure.

  Every 3 months for one year

Secondary Outcomes (3)

• WOMAC

  Every 3 months for 1 year

• WHOQOL

  Every 3 months for 1 year

• Allostatic load

  Every 3 months for 1 year

Study Arms (1)

knee pain group

adults with chronic knee pain

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients seeking physical therapy

You may qualify if:

• Adults aged 18-years old or more
• Chronic pain for 3 months or more around the knee joint.

You may not qualify if:

• Acute pain due to knee injury or surgery within the past 3 months.
• Diagnosis of lumbar radiculopathy, neuropathy or neuritis.
• Special populations i. Adults unable to consent ii. Pregnant women (self-reported) iii. Prisoners iv. George Mason University Athletes
• Military
• Bleeding disorders, blood thinners, recent blood transfusions, vasovagal syncope, and current infection.

Sponsors & Collaborators

• George Mason University: lead
• National Center for Complementary and Integrative Health (NCCIH): collaborator

Study Sites (1)

Optimal Motion Physical Therapy

Herndon, Virginia, 20170, United States

Location

Related Publications (4)

• Liang Y, Booker C. Allostatic load and chronic pain: a prospective finding from the national survey of midlife development in the United States, 2004-2014. BMC Public Health. 2024 Feb 9;24(1):416. doi: 10.1186/s12889-024-17888-1.

  PMID: 38336697 BACKGROUND

• Borsboom D, Deserno MK, Rhemtulla M, Epskamp S, Fried EI, McNally RJ, et al. Network analysis of multivariate data in psychological science. Nat Rev Methods Primer. 2021 Aug 19;1(1):1-18.

  BACKGROUND

• Fillingim RB. Individual differences in pain: understanding the mosaic that makes pain personal. Pain. 2017 Apr;158 Suppl 1(Suppl 1):S11-S18. doi: 10.1097/j.pain.0000000000000775.

  PMID: 27902569 BACKGROUND

• McBeth J, Jones K. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol. 2007 Jun;21(3):403-25. doi: 10.1016/j.berh.2007.03.003.

  PMID: 17602991 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 9, 2026
• First Posted: August 5, 2026
• Study Start: March 13, 2026
• Primary Completion (Estimated): July 31, 2029
• Study Completion (Estimated): August 1, 2029
• Last Updated: August 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share
• Time Frame: After publication of primary study results

Locations

US (1)