Effect of Single-Session HVPGS on Hand Grip Strength and Reaction Time in Healthy Individuals

NCT07745829 | Completed

• 1 other identifier: 2025-15/191
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this cross-sectional study is to investigate the immediate (acute) effects of a single session of High-Voltage Pulsed Galvanic Stimulation (HVPGS) on hand muscle strength and reaction time in healthy adults. A total of 42 healthy volunteers aged 18 to 65 years undergo a single session of HVPGS applied to the forearm flexor muscles (m. flexor digitorum superficialis, m. flexor digitorum profundus, and m. flexor pollicis longus). Isometric hand grip strength is evaluated before (T0) and immediately after (T1) the intervention using a Jamar hand dynamometer. Sensorimotor reaction time is measured at the same time points using the Nelson Hand Reaction Test. The study aims to determine whether acute HVPGS application elicits immediate bilateral enhancements in mechanical force production and central-mediated processing speed, and whether these gains interact with demographic factors or hemispheric hand dominance.

Conditions

Reaction Time; Healthy Volunteers; Muscle Strength; Neuromuscular Function

Keywords

High-Voltage Pulsed Galvanic Stimulation; Electrostimulation; Reaction Time; Neuromuscular Priming; Electrophysiology

Outcome Measures

Primary Outcomes (2)

• Immediate Change in Isometric Hand Grip Strength

  Measured in kilograms (kg) using a Jamar hydraulic hand dynamometer in a standardized seated position with 90 degrees of elbow flexion. Three consecutive trials are performed and averaged.

  Baseline (T0) and Immediately Post-Intervention (T1)

• Immediate Change in Sensorimotor Reaction Time

  Measured in centimeters (cm) using the Nelson Hand Reaction Test. Five trials are performed, and the average of the middle three values is recorded.

  Baseline (T0) and Immediately Post-Intervention (T1)

Study Arms (1)

Experimental

EXPERIMENTAL

Participants receive a single session of High-Voltage Pulsed Galvanic Stimulation (HVPGS) applied to the forearm flexor muscles (m. flexor digitorum superficialis, m. flexor digitorum profundus, and m. flexor pollicis longus). The protocol utilizes an intermittent stimulation cycle of 7 seconds of active stimulation followed by 14 seconds of rest. Immediate pre- and post-intervention evaluations measure isometric hand grip strength and sensorimotor reaction time.

Device: High-Voltage Pulsed Galvanic Stimulation (HVPGS)

Interventions

High-Voltage Pulsed Galvanic Stimulation (HVPGS) DEVICE

Application of a single session of High-Voltage Pulsed Galvanic Stimulation (HVPGS) targeting the forearm flexor muscles (m. flexor digitorum superficialis, m. flexor digitorum profundus, and m. flexor pollicis longus). The intervention uses an intermittent duty cycle consisting of 7 seconds of active stimulation followed by 14 seconds of rest, delivered under the direct supervision of an expert physiotherapist.

Experimental

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy academic and administrative staff, or senior physical therapy and rehabilitation students of Kırşehir Ahi Evran University.
• Aged between 18 and 65 years.
• Voluntary participation with signed written informed consent provided prior to enrollment.

You may not qualify if:

• Self-reported elbow, hand, shoulder, or neck discomfort in the past 6 months.
• Presence of active upper extremity pain.
• Neurological disorders affecting upper extremity sensation or motor execution.

Sponsors & Collaborators

• Kirsehir Ahi Evran Universitesi: lead

Study Sites (1)

Ahi Evran University

Kırşehir, 40100, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ömer Faruk ÖZÇELEP

Study Record Dates

• First Submitted: July 30, 2026
• First Posted: August 4, 2026
• Study Start: June 10, 2025
• Primary Completion: August 10, 2025
• Study Completion: August 11, 2025
• Last Updated: August 4, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Access Criteria: Data will become available immediately following publication of the study results and will remain accessible for up to 5 years.

Locations

TU (1)