Clinical and Radiological Outcomes of Anterior Cervical Discectomy and Fusion by Zero Profile Anchored Cage for Cervical Degenerative Disc Disease

NCT07743801 | Completed DMC

• 1 other identifier: ACDF with zero profile AC CDD
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of degenerative cervical conditions is increasing with the aging population, and it is well-recognized as a primary cause of myelopathy, radiculopathy, and disc herniation. Degenerative cervical conditions are the most prevalent conditions of the spinal cord, mainly affecting male patients over 55 years old. Currently, the treatment of degenerative spinal diseases remains focused on managing symptoms using both conservative and surgical methods. Surgical decompression can enhance neurological function and prevent future deterioration.

Conditions

Cervical Disc Disease

Outcome Measures

Primary Outcomes (2)

• Change in Neck and Arm Pain Intensity Measured by Visual Analog Scale (VAS)

  The Visual Analog Scale (VAS) is a self-reported score ranging from 0 (no pain) to 10 (worst possible pain). Higher scores indicate greater pain intensity. Pain will be assessed separately for neck, shoulder, and arm pain

  Preoperatively, and postoperatively at 1 month, 3 months, 6 months, and 12 months

• Change in Neck Functional Disability Measured by Neck Disability Index (NDI)

  The Neck Disability Index (NDI) is a questionnaire measuring functional status and disability related to neck pain, scored as a percentage from 0% (no disability) to 100% (complete disability) . Lower scores indicate better functional capacity

  Preoperatively, and postoperatively at 1 month, 3 months, 6 months, and 12 months.

Study Arms (1)

Clinical and Radiological outcomes CDD by zero profile Anchored cage

Patients with symptomatic single or multi-level cervical degenerative disc disease (C3-C4 to C6-C7) undergoing anterior cervical discectomy and fusion (ACDF) using a zero-profile anchored cage system with integrated screw fixation

Procedure: Anchored cage for CDD

Interventions

Anchored cage for CDD PROCEDURE

Radiological and clinical outcomes of Anchored cage for CDD

Clinical and Radiological outcomes CDD by zero profile Anchored cage

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients of both genders aged between 18 and 70 years admitted to the Orthopedic Surgery department at Al-Azhar University Hospitals, presenting with symptomatic single or multi-level cervical degenerative disc disease (from C3-C4 to C6-C7) causing radiculopathy or myelopathy that is refractory to conservative medical treatment, and undergoing anterior cervical discectomy and fusion (ACDF) using a zero-profile anchored cage system

You may qualify if:

• Age 18-70 years old.
• No prior cervical spine surgery.
• Cervical degenerative disease:
• Between C3-C4 to C6-C7.
• Responsible for myelopathy or radiculopathy symptoms.
• Resistant to conservative treatment.

You may not qualify if:

• Systemic, spinal, or localized infection.
• Active rheumatoid arthritis or any other medical conditions that interfere with normal healing or increase surgical risk.
• Known allergy to the implant materials used.
• Malignancy and spinal metastasis.
• Refusal to participate.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Alazhar University, Assiut

Asyut, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Orthopedic Surgery

Study Record Dates

• First Submitted: July 25, 2026
• First Posted: August 4, 2026
• Study Start: February 1, 2024
• Primary Completion: March 31, 2026
• Study Completion: April 1, 2026
• Last Updated: August 5, 2026

Record last verified: 2026-08

Locations

EG (1)