Preoperative and Postoperative Refractive and Topographic Evaluation in Patients With Primary Pterygium: Comparison of Two Surgical Techniques

NCT07742995 | Completed

• 1 other identifier: PTERYG-AC-TMA
• Study Type: interventional
• Target: 78
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study evaluated changes in refractive status and corneal topography before and after surgical treatment of primary pterygium. Patients undergoing pterygium excision were treated with either conjunctival autograft or amniotic membrane transplantation. Visual acuity, refractive error, and corneal topographic parameters were assessed before surgery and after postoperative follow-up to compare the effectiveness of both surgical techniques in restoring corneal optics and improving visual outcomes.

Conditions

Astigmatism; Primary Pterygium

Keywords

Primary Pterygium; Conjunctival Autograft; Amniotic Membrane Transplantation; Corneal Topography

Outcome Measures

Primary Outcomes (1)

• Change in Corneal Topographic Astigmatism

  Comparison of the change in corneal topographic astigmatism from baseline to 12 months after pterygium excision between conjunctival autograft and amniotic membrane transplantation.

  Baseline and 12 months after surgery

Study Arms (2)

Conjunctival Autograft

EXPERIMENTAL

Participants with primary pterygium underwent pterygium excision followed by conjunctival autograft transplantation. Postoperative refractive status, visual acuity, and corneal topographic outcomes were evaluated during a 12-month follow-up.

Procedure: Conjunctival Autograft

Amniotic Membrane Transplantation

EXPERIMENTAL

Participants with primary pterygium underwent pterygium excision followed by amniotic membrane transplantation. Postoperative refractive status, visual acuity, and corneal topographic outcomes were evaluated during a 12-month follow-up.

Procedure: Amniotic Membrane Transplantation

Interventions

Conjunctival Autograft PROCEDURE

Surgical excision of primary pterygium followed by transplantation of an autologous superior temporal conjunctival graft to cover the bare scleral bed.

Conjunctival Autograft

Amniotic Membrane Transplantation PROCEDURE

Surgical excision of primary pterygium followed by placement of preserved amniotic membrane over the bare scleral bed.

Amniotic Membrane Transplantation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older.
• Diagnosis of primary nasal pterygium in one or both eyes.
• Pterygium extending at least 1 mm onto the cornea.
• Candidate for surgical treatment and willing to undergo pterygium excision.

You may not qualify if:

• Corneal scars.
• Corneal ectatic disorders.
• History of ocular trauma.
• Previous ocular surgery.
• Cicatrizing ocular surface disease.
• Cataract or any other ocular condition that could affect visual function.

Sponsors & Collaborators

• Instituto de Oftalmología Fundación Conde de Valenciana: lead

MeSH Terms

Conditions

Astigmatism

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants with primary pterygium were assigned to one of two parallel intervention groups according to clinical and surgical criteria. One group underwent conjunctival autograft, and the other underwent amniotic membrane transplantation. Outcomes were compared after a 12-month follow-up.

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 3, 2026
• Study Start: April 1, 2013
• Primary Completion: March 1, 2015
• Study Completion: March 1, 2015
• Last Updated: August 3, 2026

Record last verified: 2026-07