Work-Related Frustration and Higher Cardiovascular Risk Blood Pressure Profiles

NCT07740434 | Recruiting DMC

• 1 other identifier: 2022-A02249-34
• Study Type: observational
• Target: 316
• Locations: 1 country
• Sites: 3

Brief Summary

Background: Mental health is a national priority in France, especially in the workplace. The impact of poor quality of life at work on mental health has been demonstrated. Raising awareness of the importance of prevention within companies and the influence of working conditions seems essential. In the context of limited occupational health physicians, inherent access difficulties, and reduced resources, physical health is often addressed as the first line of intervention. In the Burgundy region, the prevention of cardiovascular diseases is a regional public health concern. A significant association has been found between effort/reward imbalance and masked hypertension. Identifying a link between working conditions, blood pressure profile, and thus increased cardiovascular risk would be relevant. Objectives: The main goal of this observational study is to compare the frequency of blood pressure profiles at higher risk of cardiovascular events (white coat hypertension and daytime and/or nighttime masked hypertension) according to work-related quality of life and perceived stress levels among primary care patients without a history of hypertension or cardiovascular disease, in two departments of the Burgundy region. Methods: This project is a proof-of-concept study before intervention on work-related quality of life and blood pressure profiles at higher cardiovascular risk in primary prevention. It is a prospective, interventional, and multicenter study, conducted from May 2023, across three multidisciplinary primary care centers, involving fifteen general practitioners from Côte d'Or and Saône-et-Loire. Patients aged 40 to 65, consulting one of the participating general practitioners, actively working, with no cardiovascular history or antihypertensive treatment, will be included. Work-related quality of life and perceived stress will be assessed using the QualTra-Scale and the PSS-10 scale, respectively. All included patients will undergo 24-hour ambulatory blood pressure monitoring (ABPM) during a workday. A qualitative component will complement the results through patients' individual interviews exploring ABPM perception and reasons for refusal, and focus groups involving general practitioners and occupational health professionals to explore perceptions and potential intervention strategies. Perspectives: The main perspective of this study is to focus on workplace health by providing additional data on the physical repercussions of poor work-related quality of life and high perceived stress. Objectifying a confirmed medical situation could serve as a lever for identifying mental health issues. It would enable interventions to improve work-related quality of life by addressing health determinants and psychosocial risks. Various interventions could be considered through a multidisciplinary approach in the workplace, involving occupational physicians, occupational psychologists, and employers. This study could also offer insights into patient profiles at higher cardiovascular risk, help develop recommendations for screening masked hypertension, and evaluate the role of blood pressure measurements at the workplace.

Conditions

Blood Pressure Monitoring, Ambulatory; Cardiovascular (CV) Risk; Quality of Life at Work; Hypertension; Frustration

Outcome Measures

Primary Outcomes (2)

• Prevalence of masked hypertension

  Normal office blood pressure (BP \<140/90 mmHg) AND 24-hour ambulatory blood pressure hypertension (daytime BP ≥135/85 mmHg OR nighttime BP ≥120/70 mmHg)

  24-hour ambulatory blood pressure monitoring recording

• Prevalence of white-coat hypertension

  High office blood pressure (BP ≥140/90 mmHg) AND normal 24-hour ambulatory blood pressure (daytime BP \<135/85 mmHg AND nighttime BP \<120/70 mmHg)

  24-hour ambulatory blood pressure monitoring recording

Study Arms (1)

Workers from 40 to 65 years, in primary cardiovascular prevention, consulting at general practice

Working patients consulting at one of the research primary care centers, aged 40 to 65 years, with no history of hypertension or cardiovascular disease, and not taking antihypertensive medication

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Primary care working patients in primary cardiovascular prevention

You may qualify if:

• Patients aged 40 to 65 years
• Consulting one of the participating general practitioners,
• Actively working
• Without cardiovascular history or antihypertensive treatment

Sponsors & Collaborators

• University of Burgundy: lead
• Pôle Fédératif de Recherche et de Formation en Santé Publique Bourgogne-Franche-Comté: collaborator
• Laboratoire Psy-DREPI (UR 7458) - Université Bourgogne Europe: collaborator
• Département de Médecine Générale de Dijon (DMG) - Université Bourgogne Europe: collaborator

Study Sites (3)

Maison Universitaire de Santé et de Soins Primaires

Chenôve, 21300, France

RECRUITING

Cabinet médical

Chevigny-Saint-Sauveur, 21800, France

RECRUITING

Maison de Santé Pluriprofessionnelle

Pouilly-en-Auxois, 21320, France

RECRUITING

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Claire ZABAWA, Dr

CONTACT

+33699835326; claire.zabawa@u-bourgogne.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: General Practitioner - University Lecturer

Study Record Dates

• First Submitted: July 28, 2026
• First Posted: July 31, 2026
• Study Start: May 22, 2023
• Primary Completion (Estimated): May 1, 2028
• Study Completion (Estimated): May 1, 2028
• Last Updated: July 31, 2026

Record last verified: 2026-07

Locations

FR (3)