Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)

NCT07740070 | Not Yet Recruiting

• 2 other identifiers: 2024-102 SEQUOIA2025-A00021-48
• Study Type: observational
• Target: 700
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music. Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)). Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.

Conditions

Hearing Disorders and Deafness

Outcome Measures

Primary Outcomes (1)

• Correlation between neural recordings and IA models

  To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).

  Day 1

Secondary Outcomes (4)

• Compare predictions generated across different cultural contexts

  Day 1

• Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.

  From enrollement to visit 2 (10 days)

• Compare predictions generated between hearing individuals and those with hearing impairments.

  Day 2

• Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.

  Day 1

Study Arms (3)

Normal hearing participants from West Africa

Normal hearing participants from Western Europe

Participants with hearing loss

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hearing participants will be recruited from the general population in the Paris region. We will also recruit participants with hearing impairment through ENT clinics, in hearing aid dispensing centers. Finally, we will specifically recruit participants residing in Paris and of West African origin to examine differences related to cultural experience.

You may qualify if:

• For hearing participants:
• Average pure-tone thresholds ≤ 20 dB HL
• For participants with hearing loss:
• Average pure-tone thresholds \> 20 dB HL
• For participants of West African origin:
• Average pure-tone thresholds ≤ 20 dB HL
• Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.

You may not qualify if:

• No known neurological or audiological disorders
• Participants under legal guardianship (tutelle, curatelle)
• Participants deprived of legal liberty by judicial or administrative decision

Sponsors & Collaborators

• Institut Pasteur: lead
• IHU reConnect: collaborator

MeSH Terms

Conditions

Hearing Disorders; Deafness

Condition Hierarchy (Ancestors)

Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hearing Loss

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: July 31, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): November 1, 2030
• Study Completion (Estimated): November 1, 2033
• Last Updated: July 31, 2026

Record last verified: 2026-06