Efficacy of Liquid Phase Concentrated Growth Factors as an Adjunct to EDTA in the Treatment of Recession Type 1 Defect With Free Gingival Graft

NCT07736833 | Completed

• 1 other identifier: FGG with EDTA and LPCGF
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The present study was designed to investigate the clinical efficacy of liquid-phase concentrated growth factors (LPCGF) as an adjunct to ethylenediaminetetraacetic acid (EDTA) for root surface biomodification prior to free gingival grafting for the management of Cairo type 1 gingival recession defects.

Conditions

Gingival Recession

Keywords

FGG with EDTA and LPCGF root biomodification

Outcome Measures

Primary Outcomes (2)

• Width of attached gingiva (AG)

  calculated by subtracting probing pocket depth from the width of keratinized gingiva measured from the free gingival margin to the mucogingival junction, as determined by the roll technique

  Baseline, 1 month, 3 months, and 6 months

• Gingival thickness (GT)

  baseline, 1 month, 3 months, and 6 months

Secondary Outcomes (5)

• Probing pocket depth (PPD)

  baseline and 6 months postoperative

• Recession width (RW)

  Baseline, 1 month, 3 months, and 6 months.

• Recession depth (RD)

  baseline, 1 month, 3 months, and 6 months

• Clinical attachment level (CAL)

  base line and 6 months postoperative

• Percentage of root coverage (RC)

  6 months postoperative

Study Arms (2)

Group I: Free gingival graft (FGG) with EDTA root surface biomodification

ACTIVE COMPARATOR

Group I: Free gingival graft (FGG) with EDTA root surface biomodification

Procedure: Free gingival graft (FGG) with EDTA root surface biomodification

Group II: Free gingival graft (FGG) with EDTA and LPCGF root surface

EXPERIMENTAL

Group II: Free gingival graft (FGG) with EDTA and LPCGF root surface

Procedure: Free gingival graft (FGG) with EDTA and LPCGF root surface application

Interventions

Free gingival graft (FGG) with EDTA and LPCGF root surface application PROCEDURE

Free gingival graft (FGG) with EDTA and LPCGF root surface biomodification

Group II: Free gingival graft (FGG) with EDTA and LPCGF root surface

Free gingival graft (FGG) with EDTA root surface biomodification PROCEDURE

Free gingival graft (FGG) with EDTA root surface biomodification

Group I: Free gingival graft (FGG) with EDTA root surface biomodification

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18 to 50 years old.
• Patients with good systemic health with no contraindication for periodontal surgery.
• No history of systemic or local medications within the previous six months that could affect periodontal tissue health or wound healing.
• Recession depth ≥ 3 mm, measured from the cementoenamel junction (CEJ) to the gingival margin and/ or width of attached gingiva \< 3 mm.
• Presence of identifiable cementoenamel junction (CEJ).
• Absence of interproximal attachment loss (i.e., intact interdental bone and soft tissue, confirmed radiographically).
• Ability to maintain adequate oral hygiene, as demonstrated during recall visits.

You may not qualify if:

• Restoration or caries in the site to be treated or non-vital tooth.
• Previous mucogingival surgery at the defect.
• Active infectious diseases (hepatitis, HIV, etc.).
• Smokers and pregnant patients.
• Teeth that are tilted rotated or have any non-alterable occlusal abnormalities.
• Sites with tooth mobility.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

faculty of dentistry, Tanta university

Tanta, Gharbia Governorate, 31773, Egypt

Location

MeSH Terms

Conditions

Gingival Recession

Interventions

fibrinopeptides gamma

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching assistant

Model Details: The 20 sites will be classified randomly by the sealed envelope technique into the two treatment groups, 10 sites in each group.

Study Record Dates

• First Submitted: July 26, 2026
• First Posted: July 30, 2026
• Study Start: February 21, 2024
• Primary Completion: February 21, 2025
• Study Completion: May 20, 2025
• Last Updated: July 30, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)