Exercise Therapy for Women With ANOCA

NCT07733986 | Not Yet Recruiting

• 1 other identifier: GN26CA170
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 11

Brief Summary

Angina is a feeling of chest pain or discomfort which can happen if there is reduced blood flow to the heart. Patients can experience angina with no obstructive coronary arteries (ANOCA) which is a difficult condition to treat (ie relieve angina) since few randomised, controlled therapy trials have been undertaken for ANOCA. Until now, angina has been mainly studied in men even though women are at least two-fold more likely than men to experience ANOCA. In 2023, a Scientific Statement from the American Heart Association affirmed that resistance exercise training can improve or maintain muscle mass and strength and confer favourable physiological and clinical effects on cardiovascular disease and risk factors. Resistance exercise has not been assessed in ANOCA and it offers an important opportunity to study non drug alternatives to treatment for women. This study will use a resistance based exercise programme to investigate if symptoms of ANOCA can be improved in women. It will recruit at least 76 patients (maximum 152 patients) across 13 hospitals in the UK and the Netherlands. The study will use a randomised wait list control design. This means all participants will be offered the intervention, but the randomisation will decide when they undergo it. It is part of a platform of trials for women with ANOCA. We are also setting up a drug study called ANOCA Therapy and a cohort study called ANOCA- Diagnosis.

Conditions

Angina Patients With Non-obstructive Coronary Artery Disease

Keywords

Angina; Women; Resistance exercise; Cardiovascular disease; Clinical trial

Outcome Measures

Primary Outcomes (1)

• Seattle Angina Questionnaire

  The Seattle Angina Questionnaire a validated 19-item patient-reported survey used to measure coronary artery disease and angina treatment efficacy. Patients will complete on paper or electronically. The scores range from 0 to 100, with higher scores indicating less frequent angina, improved function, and better quality of life.

  Change from Baseline to Week 9

Secondary Outcomes (12)

• Myocardial perfusion reserve (MPR)

  Change from baseline to week 9

• Handgrip strength using hand dynamometer

  Change from baseline to week 9

• Short Physical Performance Battery (SPPB)

  Change from baseline to week 9

• Brief Illness perception Questionnaire (Brief IPQ)

  Change from baseline to week 9

• Patient Health Questionnaire-4 of (PHQ4)

  Change from Baseline to Week 9

Study Arms (2)

Intervention

EXPERIMENTAL

Allocated to exercise intervention first

Behavioral: Resistance based exercise

Control

ACTIVE COMPARATOR

Allocated to exercise intervention second

Behavioral: Resistance based exercise

Interventions

Resistance based exercise BEHAVIORAL

Participants will undergo daily resistance based exercise for 8 weeks

Control; Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Angina with no obstructive coronary arties (ANOCA)
• Myocardial perfusion reserve or coronary flow reserve recorded within three years
• Seattle Angina Questionnaire frequency score ≤60
• Duke Activity Status Index ≤34
• Female sex

You may not qualify if:

• Age \<18 years
• Unable to provide informed consent
• \- Unable to comply with the protocol
• Pregnancy
• Currently undertaking resistance exercise activities

Sponsors & Collaborators

• NHS Greater Glasgow and Clyde: lead
• The University of Glasgow: collaborator

Study Sites (11)

Basildon University Hospital

Basildon, United Kingdom

Location

Royal United Hospital Bath

Bath, United Kingdom

Location

Royal Papworth Hospital

Cambridge, United Kingdom

Location

Queen Elizabeth University Hospital Clinical Research Facility

Glasgow, G51 4TF, United Kingdom

Location

Leeds General Infirmary

Leeds, United Kingdom

Location

Brompton Hospital

London, United Kingdom

Location

Guy and St Thomas Hospital

London, United Kingdom

Location

Kings College Hospital

London, United Kingdom

Location

Freeman Hospital

Newcastle upon Tyne, United Kingdom

Location

Nottingham City Hospital

Nottingham, United Kingdom

Location

Sunderland Royal hospital

Sunderland, United Kingdom

Location

MeSH Terms

Conditions

Angina Pectoris; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Colin Berry

  The University of Glasgow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Clare Dolan

CONTACT

0141 314 4328; clare.dolan3@nhs.scot

PMU Mail box

CONTACT

0141 314 4328; ggc.pmu.research@nhs.scot

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomised, open-label, parallel group, waiting list controlled clinical trial

Study Record Dates

• First Submitted: July 20, 2026
• First Posted: July 29, 2026
• Study Start (Estimated): September 14, 2026
• Primary Completion (Estimated): June 30, 2029
• Study Completion (Estimated): June 30, 2029
• Last Updated: July 29, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: After the study has completed
• Access Criteria: Bone fide collaboration request

Locations

GB (11)