NCT07732478

Brief Summary

This study evaluates the effects of a community-based multicomponent exercise program on physical function, frailty, and sarcopenia in older adults living in the municipality of Santoña (Cantabria, Spain). The exercise program is organized and delivered by the Santoña Town Council as part of its public health services for older residents and is not created for research purposes; it will continue regardless of the outcome of this study. Researchers are only evaluating participants who voluntarily agree to be assessed before and after each 36-week cycle of the program, over four consecutive academic years (2026-2030). The main question this study aims to answer is whether continued participation in this real-world, community-based multicomponent exercise program (based on the Vivifrail model) leads to meaningful improvements in physical function, muscle strength, and cardiorespiratory capacity, and helps reverse indicators of frailty and sarcopenia in independent, community-dwelling older adults. Participants will complete functional and physical tests, including balance, gait speed, chair-stand performance, handgrip strength, and a 6-minute walk test, at the start and end of each 36-week exercise cycle. No blood or biological samples will be collected.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for not_applicable

Timeline
47mo left

Started Oct 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 23, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 29, 2026

Completed
2 months until next milestone

Study Start

First participant enrolled

October 1, 2026

Expected
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2030

2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2030

Last Updated

July 30, 2026

Status Verified

July 1, 2026

Enrollment Period

3.7 years

First QC Date

July 23, 2026

Last Update Submit

July 28, 2026

Conditions

Keywords

Multicomponent exerciseCommunity-based exercise programOlder adultsPhysical functionFrailty preventionSarcopeniaMuscle strengthCardiorespiratory fitnessFall preventionReal-world effectiveness

Outcome Measures

Primary Outcomes (1)

  • Short Physical Performance Battery (SPPB) score

    Composite score assessing lower-extremity physical function through three components - standing balance, 4-meter gait speed, and time to complete five repeated chair stands. Total score ranges from 0 to 12, with lower scores indicating greater physical frailty.

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

Secondary Outcomes (6)

  • Handgrip strength

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

  • 30-Second Chair Stand Test

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

  • 6-Minute Walk Test (6MWT) distance

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

  • Body weight and Body Mass Index (BMI)

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

  • Waist circumference

    Baseline (week 0) and post-intervention (week 36), for each of the four annual cohorts (2026-2030)

  • +1 more secondary outcomes

Study Arms (1)

Community Multicomponent Exercise Program

EXPERIMENTAL

Participants aged 65 and older meeting the inclusion criteria take part in the pre-existing 36-week multicomponent exercise program delivered by the Santoña Town Council. Functional and physical assessments are performed at baseline (week 0) and at the end of each 36-week cycle (week 36), across four consecutive academic years. Each participant serves as their own control.

Behavioral: Multicomponent Exercise Program (Vivifrail-based)

Interventions

A 36-week community-based multicomponent exercise program addressing strength, balance, endurance, and flexibility, structured according to the Vivifrail FITT-VP model. Sessions are delivered by qualified exercise professionals as part of the Santoña Town Council's existing public health services, independently of this study.

Community Multicomponent Exercise Program

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Age 65 years or older
  • Independent, community-dwelling (not institutionalized)
  • Barthel Index score ≥ 90 points (no significant disability)
  • Timed Up and Go (TUG) test ≥ 10 seconds
  • Short Physical Performance Battery (SPPB) score below 12 points (indicating possible frailty)
  • Fall risk indicated by at least one of the following: one fall in the past year requiring assistance, more than one fall without assistance, TUG \> 20 seconds, or gait speed over 6 meters \> 7.50 seconds
  • Reduced grip strength: below 27 kg (men) or below 16 kg (women), or more than 15 seconds to complete 5 chair stands
  • Voluntary signed informed consent

You may not qualify if:

  • Terminal illness
  • Residing in a nursing home
  • Diagnosed with, or under investigation for, moderate to severe cognitive impairment
  • Unstable cardiovascular disease
  • Acute infectious disease
  • Uncontrolled hypertension (systolic \> 180 mmHg or diastolic \> 110 mmHg)
  • Uncontrolled diabetes
  • Advanced organ failure
  • Disabling musculoskeletal condition

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Sports Science

Granada, Andalusia, 18004, Spain

Location

MeSH Terms

Conditions

FrailtySarcopenia

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and SymptomsMuscular AtrophyNeuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalSigns and Symptoms

Study Officials

  • Andrés B. Fernández-Revelles, Sport Science

    Universidad de Granada

    PRINCIPAL INVESTIGATOR

Central Study Contacts

JAVIER Fernández-Ortega, PhD Student, Sports Science

CONTACT

Andrés B. Fernández-Revelles, Sport Sciences

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Andrés B. Fernández-Revelles, Principal Investigator, Associate Professor; Javier Fernández-Ortega, PhD Student

Study Record Dates

First Submitted

July 23, 2026

First Posted

July 29, 2026

Study Start (Estimated)

October 1, 2026

Primary Completion (Estimated)

June 1, 2030

Study Completion (Estimated)

July 31, 2030

Last Updated

July 30, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will share

De-identified individual participant data collected during the study (anthropometric, functional, and cardiorespiratory outcome measures) will be made available, along with an accompanying data dictionary describing all variables collected.

Shared Documents
STUDY PROTOCOL, SAP, ANALYTIC CODE
Time Frame
Beginning after publication of the main results article associated with each cohort, with no specified end date.
Access Criteria
Data will be made available to researchers who provide a methodologically sound proposal, upon reasonable request to the corresponding author. Requests should specify the intended use of the data and will be reviewed by the research team.

Locations