Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery

NCT07732465 | Not Yet Recruiting Phase 2

• 1 other identifier: 2026-3693 MHI
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery

Conditions

Coronary Artery Bypass Grafting (CABG) Surgery; Saphenectomy

Keywords

Adductor canal block; Numeric Rating Scale (NRS); Coronary artery bypass grafting (CABG); Saphenectomy; Postoperative period; Placebo-controlled

Outcome Measures

Primary Outcomes (1)

• Leg Pain at Rest

  The primary outcome will be leg pain at rest, measured using a numeric rating scale (NRS 0-10) at 3 hours, 6 hours, 12 hours, and 24 hours after the block injection. The NRS (Numeric Rating Scale) is a validated and widely used tool for assessing pain intensity in adults, particularly in postoperative and critical care settings. It allows for a simple, reproducible, and easily administered measurement, including during repeated assessments at the patient's bedside. The NRS scale consists of asking the patient to rate their pain on a numeric scale from 0 to 10, where: 0 corresponds to no pain at all 10 corresponds to the worst pain imaginable

  Numeric rating scale (NRS 0-10) will be performed at 3 hours, 6 hours, 12 hours, and 24 hours after the block injection.

Secondary Outcomes (9)

• Total opioid consumption

  The first 48 postoperative hours after procedure

• Postoperative pain unrelated to the saphenous territory

  Numeric rating scale (NRS 0-10) performed at 3 hours, 6 hours, 12 hours, and 24 hours after the block injection.

• Persistent Postoperative Pain

  At 3 and 6 months postoperatively, assessed using the NRS.

• Overall persistent postoperative pain

  At 3 and 6 months postoperatively.

• Presence of hypoesthesia

  Numeric rating scale at 3 and 6 months.

Other Outcomes (3)

• Use of co-analgesia

  Assessed once daily total co-analgesic doses administered, until discharge (an average of 7 days), up to 60 days.

• Postoperative quality of life

  At 3 and 6 months postoperatively

• Opioid use

  At 3 and 6 months postoperatively

Study Arms (2)

Adductor canal bloc with bupivacaine + dexmedetomidine

EXPERIMENTAL

Procedure: Aductor canal bloc

Control arm

PLACEBO COMPARATOR

Saline solution

Procedure: Control adductor canal block

Interventions

Aductor canal bloc PROCEDURE

Adductor canal bloc with 0,25% bupivacaine + 20 ucg of dexmedetomidine

Also known as: Pain relief arm

Adductor canal bloc with bupivacaine + dexmedetomidine

Control adductor canal block PROCEDURE

Needle insertion mimicking the ACB procedure with injection of a saline solution

Control arm

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Planned CABG with unilateral or bilateral great saphenous vein (GSV) harvesting, without concomitant valve surgery
• Age ≥ 18 years
• Ability to understand the protocol and provide written informed consent
• ASA physical status I-IV

You may not qualify if:

• Refusal to participate in the study or inability to provide written informed consent
• Contraindication to adductor canal block (e.g., local infection, allergy to local anesthetics)
• Pre-existing chronic pain associated with chronic use of analgesic medications other than acetaminophen
• Pre-existing peripheral neuropathy affecting the leg
• Participation in two other interventional studies at the Montreal Heart Institute
• Endoscopic vein harvesting performed by the surgical team instead of open saphenectomy technique

Sponsors & Collaborators

• Montreal Heart Institute: lead

Study Sites (1)

Montreal Heart Institute

Montreal, Quebec, H1T 1C8, Canada

Location

Related Publications (30)

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  BACKGROUND

Central Study Contacts

Christian Ayoub, MD

CONTACT

5147088999; ayoub_christian@hotmail.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 2, 2026
• First Posted: July 29, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: July 29, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)