Effectiveness of Three Different Irrigation Methods During a Root Canal Treatment

NCT07731594 | Not Yet Recruiting

• 1 other identifier: SOD/ERB/2025/89
• Study Type: interventional
• Target: 105
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to compare the effectiveness of three root canal irrigation techniques-Conventional Needle Irrigation (CNI), Side-Vented Needle (SVN), and Ultrasonic Irrigation (UI)-in achieving irrigant penetration into the apical third of the root canal. Since conventional irrigation often fails to adequately clean complex root canal anatomy, the study evaluates whether activation methods improve irrigant penetration. A randomized controlled trial will compare these three techniques using extracted single-rooted mandibular premolars. A radiopaque dye mixed with sodium hypochlorite will be used to measure irrigant penetration on digital radiographs, and the results will be statistically analyzed to determine the most effective irrigation method.

Conditions

Three Canal Irrigation Methods and Their Comparison; Penetration of Irrigant in the Root Canal

Outcome Measures

Primary Outcomes (1)

• Depth of irrigant penetration into the apical third of the root canal (measured in millimeters).

  The primary outcome is the depth of penetration of a radiopaque irrigant solution into the apical third of the root canal following irrigation with Conventional Needle Irrigation (CNI), Side-Vented Needle Irrigation (SVN), or Ultrasonic Irrigation (UI). Penetration depth will be measured on digital radiographs as the distance from the apical foramen to the deepest point reached by the irrigant.

  5 months

Study Arms (3)

Conventional Needle Irrigation

ACTIVE COMPARATOR

Participants in this group will receive root canal irrigation using a conventional 27-gauge syringe needle. The irrigant, consisting of a radiopaque iohexol dye mixed with 5.25% sodium hypochlorite, will be delivered into the prepared root canal using the conventional needle irrigation technique. Irrigant penetration into the apical third will be assessed using digital radiographs.

Procedure: Conventional Needle

Side Vented Needle Irrigation

ACTIVE COMPARATOR

Participants in this group will receive root canal irrigation using a side-vented irrigation needle. The radiopaque irrigant solution, prepared by mixing iohexol dye with 5.25% sodium hypochlorite, will be delivered into the canal using the side-vented needle technique. Irrigant penetration into the apical third will be measured on digital radiographs.

Procedure: Side Vented Needle

Ultrasonic Irrigation

EXPERIMENTAL

Participants in this group will receive ultrasonic irrigation following completion of canal preparation. A radiopaque irrigant solution consisting of iohexol dye mixed with 5.25% sodium hypochlorite will be ultrasonically activated within the root canal. Digital radiographs will be used to measure the depth of irrigant penetration into the apical third and compare it with the other irrigation techniques

Procedure: Ultrasonic Irrigation

Interventions

Conventional Needle PROCEDURE

Conventional syringe irrigation will be performed using a 27-gauge needle to deliver the radiopaque sodium hypochlorite solution into the prepared root canal. No additional activation technique will be used during irrigation

Conventional Needle Irrigation

Side Vented Needle PROCEDURE

Irrigation will be carried out using a side-vented needle to introduce the radiopaque sodium hypochlorite solution into the prepared canal. The side-vented design is intended to improve irrigant distribution within the canal while minimizing direct apical flow

Side Vented Needle Irrigation

Ultrasonic Irrigation PROCEDURE

Following canal preparation, the radiopaque sodium hypochlorite solution will be activated using an ultrasonic device to enhance irrigant movement throughout the root canal system before radiographic evaluation of penetration depth.

Ultrasonic Irrigation

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Straight Canals
• Single Rooted 1st and 2nd mandibular premolars with closed apices

You may not qualify if:

• Mandibular premolars with open apices
• Mandibular premolars with curved or calcified canals

Sponsors & Collaborators

• Pakistan Institute of Medical Sciences: lead

Study Officials

• Haroon H Panezai, BDS

  School Of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Haroon H Panezai, BDS

CONTACT

+923128708722; haroonhpanezai@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: July 28, 2026
• Study Start: July 12, 2026
• Primary Completion (Estimated): November 10, 2026
• Study Completion (Estimated): December 26, 2026
• Last Updated: July 28, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share