Efficacy of IPL, an Anti-redness Dermocosmetic, and Their Combination in the Treatment of Rosacea

NCT07729540 | Completed

• 1 other identifier: KNW/0022/KB//II/16/17
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares three approaches to treating persistent facial redness in adults with erythematotelangiectatic rosacea: intense pulsed light (IPL) treatment alone, a professional anti-redness dermocosmetic skincare regimen alone, and the combination of both. The main question the study aims to answer is which of these three strategies is more effective at reducing facial redness, using both clinician grading and objective skin-imaging tools that measure redness and skin texture before and after treatment.

Conditions

Rosacea

Keywords

Erythema; Intense Pulsed Light; Dermocosmetic; Antera 3D Chromophore Mapping; Gray-Level Co-Occurrence Matrix Texture Analysis; Clinician Erythema Assessment; Lumecca; Rosacure

Outcome Measures

Primary Outcomes (1)

• Antera 3D Erythema Index (Mean, Minimum, and Maximum)

  Erythema quantified via the Antera 3D camera (Miravex, Dublin, Ireland), which reconstructs hemoglobin distribution from multidirectional, multispectral light reflectance and expresses erythema on a reproducible relative scale. For each patient and time point, three erythema indices - mean, minimum, and maximum - were extracted for the left and right cheek and averaged into a single value per index.

  Baseline, 2 weeks after the treatment series, and 8 weeks after the treatment series

Secondary Outcomes (3)

• GLCM Contrast

  Baseline, 2 weeks after the treatment series, and 8 weeks after the treatment series

• GLCM Homogeneity

  Baseline, 2 weeks after the treatment series, and 8 weeks after the treatment series

• Clinician Erythema Assessment (CEA) Score

  Baseline, 2 weeks after the treatment series, and 8 weeks after the treatment series

Study Arms (3)

IPL Monotherapy (Lumecca)

EXPERIMENTAL

Three intense pulsed light (IPL) treatments using the Lumecca applicator (InMode; 515-1200 nm) at 21-day intervals. Fluence was individually titrated to skin response and increased across sessions. Broad-spectrum sunscreen SPF 50+ was applied after each session, and daily photoprotection was mandatory.

Device: Intense Pulsed Light (IPL) - Lumecca

Dermocosmetic Regimen (Rosacure Professional)

EXPERIMENTAL

Four professional in-office anti-redness treatments using the Rosacure Professional system (Synchroline/Cantabria Labs) at 7-day intervals: gentle cleansing, application of Rosacure Professional Serum Booster (4-t-butylcyclohexanol, niacin amide, panthenol, sodium hyaluronate, polyglutamic acid), and a leave-on regenerating gel mask. Concurrently, a standardized 12-week home-care regimen: twice-daily gentle cleanser, Rosacure Intensive SPF 30 each morning, Rosacure Fast each evening, and a leave-on mask twice weekly.

Other: Rosacure anti-redness dermocosmetic regimen

Combined IPL and Dermocosmetic Therapy

EXPERIMENTAL

Three IPL treatments identical to Arm 1 (Lumecca applicator, 515-1200 nm, 21-day intervals), immediately followed within the same session by the professional Rosacure protocol described in Arm 2, together with the same 12-week home-care regimen used in Arm 2.

Device: Intense Pulsed Light (IPL) - Lumecca; Other: Rosacure anti-redness dermocosmetic regimen

Interventions

Intense Pulsed Light (IPL) - Lumecca DEVICE

IPL treatment (515-1200 nm) delivered with the Lumecca applicator (InMode, Irvine, CA, USA), administered as three sessions at 21-day intervals with fluence individually titrated to skin response.

Combined IPL and Dermocosmetic Therapy; IPL Monotherapy (Lumecca)

Rosacure anti-redness dermocosmetic regimen OTHER

Professional in-office anti-redness regimen (Rosacure Professional system: gentle cleansing, Rosacure Professional Serum Booster, leave-on regenerating gel mask) plus a standardized 12-week home-care regimen (Rosacure Intensive SPF 30 mornings, Rosacure Fast evenings, leave-on mask twice weekly), manufactured by Synchroline/Cantabria Labs, Spain.

Combined IPL and Dermocosmetic Therapy; Dermocosmetic Regimen (Rosacure Professional)

Eligibility Criteria

• Age: 20 Years - 57 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adult patients with a dermatologist-confirmed diagnosis of erythematotelangiectatic rosacea

You may not qualify if:

• Age under 18 years
• Pregnancy or breastfeeding
• Predisposition to keloid or hypertrophic scarring
• Use of systemic or topical retinoids, antibiotics, or hormonal therapy within the washout period specified for each agent
• Chemical peeling within one month
• Laser treatment or phototherapy within three months
• Photosensitizing medications or herbal preparations
• Inflammatory dermatoses other than rosacea
• Autoimmune disease
• Active skin infection in the treatment area

Sponsors & Collaborators

• Medical University of Silesia: lead
• Synchroline/Cantabria Labs: collaborator

Study Sites (1)

Medical University of Silesia

Sosnowiec, 41-200, Poland

Location

Related Publications (7)

• Ou X, Pan W, Xiao P. In vivo skin capacitive imaging analysis by using grey level co-occurrence matrix (GLCM). Int J Pharm. 2014 Jan 2;460(1-2):28-32. doi: 10.1016/j.ijpharm.2013.10.024. Epub 2013 Nov 2.

  PMID: 24188984 BACKGROUND

• Crea F, Pupita G, Galassi AR, el Tamimi H, Kaski JC, Davies GJ, Maseri A. Effect of theophylline on exercise-induced myocardial ischaemia. Lancet. 1989 Apr 1;1(8640):683-6. doi: 10.1016/s0140-6736(89)92204-6.

  PMID: 2564505 BACKGROUND

• Seo JK, Shin EJ, Jeong KH, Shin MK. Clinician Severity Assessment Grading Scale on Erythematotelangiectatic Rosacea. Indian J Dermatol. 2021 Mar-Apr;66(2):203-205. doi: 10.4103/ijd.IJD_611_19. No abstract available.

  PMID: 34188282 BACKGROUND

• Tan J, Liu H, Leyden JJ, Leoni MJ. Reliability of Clinician Erythema Assessment grading scale. J Am Acad Dermatol. 2014 Oct;71(4):760-3. doi: 10.1016/j.jaad.2014.05.044. Epub 2014 Jul 4.

  PMID: 24999270 BACKGROUND

• Piccolo D, Fusco I, Zingoni T, Conforti C. Effective Treatment of Rosacea and Other Vascular Lesions Using Intense Pulsed Light System Emitting Vascular Chromophore-Specific Wavelengths: A Clinical and Dermoscopical Analysis. J Clin Med. 2024 Mar 13;13(6):1646. doi: 10.3390/jcm13061646.

  PMID: 38541871 BACKGROUND

• Zhai Q, Cheng S, Liu R, Xie J, Han X, Yu Z. Meta-Analysis of the Efficacy of Intense Pulsed Light and Pulsed-Dye Laser Therapy in the Management of Rosacea. J Cosmet Dermatol. 2024 Dec;23(12):3821-3827. doi: 10.1111/jocd.16549. Epub 2024 Sep 6.

  PMID: 39240125 BACKGROUND

• Sulk M, Seeliger S, Aubert J, Schwab VD, Cevikbas F, Rivier M, Nowak P, Voegel JJ, Buddenkotte J, Steinhoff M. Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol. 2012 Apr;132(4):1253-62. doi: 10.1038/jid.2011.424. Epub 2011 Dec 22.

  PMID: 22189789 BACKGROUND

MeSH Terms

Conditions

Rosacea; Erythema

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Anna Deda, PhD

  Medical University of Silesia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: July 27, 2026
• Study Start: September 29, 2025
• Primary Completion: April 30, 2026
• Study Completion: April 30, 2026
• Last Updated: July 27, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Available upon reasonable request from the corresponding author, beginning from the date of publication, with no specified end date.
• Access Criteria: Data will be made available to qualified researchers who submit a reasonable request to the corresponding author (Anna Deda, adeda@sum.edu.pl), for the purpose of methodologically sound reanalysis, subject to authors' approval.

Locations

PL (1)