Relation Between Glycemic Control and Retinal Microvascular Changes in Diabetic Patients Using OCTA

NCT07726381 | Not Yet Recruiting

• 1 other identifier: Sohag university
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

An observational cross-sectional comparative study which will be conducted in the Department of Ophthalmology, Sohag University Hospital, Egypt to detect the relation between glycemic control and retinal microvascular changes in diabetic patients using OCTA

Conditions

Diabetic Retinopathy (DR); Retinal Microvascular Changes

Keywords

retinal microvascular changes; diabetic retinopathy; Optical coherence topography

Outcome Measures

Primary Outcomes (1)

• OCT findings

  OCTA images and data will be collected and analysed from the electronic medical reports for all patients to detect micro-vascular changes in the form of : 1. Vascular density ( superficial and deep plexuses )in square millimeters (mm²). 2. Foveal Avascular Zone ( FAZ ) in percentage

  1 year

Study Arms (1)

This study will include 50 eyes of diabetic patients divided into: Group 1: 25 eyes of diabetic pati

This study will include 50 eyes of diabetic patients divided into: Group 1: 25 eyes of diabetic patients with controlled HbA1c Group 2: 25 eyes of diabetic patients with uncontrolled HbA1c,

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

50 eyes of diabetic patients with with diabetic retinopathy with controlled and uncontrolled HbA1c

You may qualify if:

• Diabetic patients with diabetic retinopathy with controlled and uncontrolled HbA1c

You may not qualify if:

• Media opacities affecting OCT imaging (corneal pathologies, dense cataracts, vitreous opacities, etc).
• Patients with any other retinal vascular diseases (retinal vein occlusion, central serrous chorioretinopathy, age-related macular degeneration, etc).
• Patients who have had previous intravitreal injections or Laser treatment.
• Patients who underwent previous vitreoretinal surgeries.
• Patients with recent history of undergoing cataract surgery.
• Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis).

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Diabetic Retinopathy

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases; Diabetic Angiopathies; Vascular Diseases; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases

Study Officials

• Al Ahmady Al Samman, Professor

  Faculty of Medicine, Sohag university

  STUDY DIRECTOR

• Hany Mahmoud, Assist.Prof

  Faculty of Medicine, Sohag university

  STUDY DIRECTOR

Central Study Contacts

Nourhan Ahmed, Resident

CONTACT

+201144486792; nourhanaymanpost@med.sohag.edu.eg

Sara Mahmoud, Lecturer

CONTACT

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Rediant of Opthalmology department

Study Record Dates

• First Submitted: July 20, 2026
• First Posted: July 24, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: July 24, 2026

Record last verified: 2026-07