NCT07725744

Brief Summary

This study aims to investigate the interface pressure changes of single-layer with 10% circumferential reduction (S-10), single-layer with 15% circumferential reduction (S-15), and dorsal double-layered with 10% circumferential reduction (DD-10)pressure garments over time, their relationships with adherence and adverse events, and their effects on tactile gnosis. Participants will:

  1. 1.Wear S-10, S-15, or DD-10 for at least 12 hours daily for four weeks
  2. 2.Measure interface pressure at baseline and weekly
  3. 3.Assess tactile gnosis at baseline, Week 2, and Week 4
  4. 4.Record adherence and adverse events using a self-report logbook

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Jul 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress6%
Jul 2026Mar 2027

Study Start

First participant enrolled

July 20, 2026

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

July 21, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 24, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2027

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2027

Last Updated

July 24, 2026

Status Verified

July 1, 2026

Enrollment Period

7 months

First QC Date

July 21, 2026

Last Update Submit

July 21, 2026

Conditions

Keywords

interface pressurepressure garmentpressure changestactile gnosisadherencesafetyStroke RehabilitationOccupational Therapy

Outcome Measures

Primary Outcomes (1)

  • Interface pressure measured using PicoPress® Compression System

    The change in interface pressure over time and the group-by-time difference in pressure trajectories among the three pressure garment groups. PicoPress® Compression System is a portable pneumatic measuring system designed to measure interface pressure exerted by pressure garment, medical compression bandage or other compression therapeutic materials.

    Baseline, Week-1, Week-2, Week-3, and Week-4

Secondary Outcomes (3)

  • Shape/Texture Identification (STI) test

    Baseline, Week-2, and Week-4

  • Daily Self-Report and Adverse Events of Special Interest (AESI) Logbook

    Completed by participants or caregiver daily, reviewed weekly by researcher

  • Modified Ashworth Score (MAS)

    Baseline, Week-1, Week-2, Week-3, and Week-4

Other Outcomes (2)

  • Montreal Cognitive Assessment (MoCA) - Bahasa Malaysia version

    Prior to participant enrolment

  • Modified Ashworth Score (MAS)

    Prior to participant enrolment

Study Arms (3)

Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

ACTIVE COMPARATOR

A customized single-layered finger-to-above-elbow (long glove) pressure garment with 10% circumferential reduction.

Other: Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

EXPERIMENTAL

A customized finger-to-above-elbow (long glove) pressure garment with 10% of circumferential reduction. The design is similar to S-10 except it has an extra layer of fabric on the dorsal aspect that provides more compression.

Other: Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

Single-Layered 15% Circumferential Reduction (S-15) Pressure Garment

ACTIVE COMPARATOR

A customized single-layered finger-to-above-elbow (long glove) pressure garment with 15% circumferential reduction.

Other: Single-Layered 15% Circumferential Reduction (S-15) Pressure Garment

Interventions

Each participant will receive a dorsal doubled-layered 10% circumferential reduction (DD-10) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

Each participant will receive a single-layered 10% circumferential reduction (S-10) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

Each participant will receive a single-layered 15% circumferential reduction (S-15) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

Single-Layered 15% Circumferential Reduction (S-15) Pressure Garment

Eligibility Criteria

Age21 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • adults aged between 21 years to 60 years old
  • a history of stroke (no restrictions on the stroke type)
  • Modified Ashworth Scale of 1, 1+ or 2 when hand performing flexion and extension
  • no cognitive impairment (Montreal Cognitive Assessment (MoCA ⩾ 21)

You may not qualify if:

  • skin lesions, infections or other skin problems
  • serious circulatory problems such as deep vein thrombosis
  • hypersensitive to Lycra materials
  • behavioural disturbances or motor impairments caused by other orthopaedic or neurological conditions other than stroke

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Stroke

Interventions

S 10EFEMP1 protein, human

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 21, 2026

First Posted

July 24, 2026

Study Start

July 20, 2026

Primary Completion (Estimated)

January 31, 2027

Study Completion (Estimated)

March 31, 2027

Last Updated

July 24, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share