NCT07725198

Brief Summary

This study used a prospective, randomized, repeated-measures experimental design to investigate the immediate effects of two upper cervical manual therapy interventions on craniovertebral angle (CVA), clinician-perceived atlas position, and musculoskeletal ultrasound-derived obliquus capitis inferior (OCI) muscle morphology

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
10mo left

Started May 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress60%
May 2025Jun 2027

Study Start

First participant enrolled

May 1, 2025

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

July 21, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 24, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

July 24, 2026

Status Verified

July 1, 2026

Enrollment Period

1.7 years

First QC Date

July 21, 2026

Last Update Submit

July 21, 2026

Conditions

Head and NeckHeadache

Outcome Measures

Primary Outcomes (1)

  • MSK Ultrasound

    MSK Ultrasound measure of the Obliquues Capitis inferior muscle lenght and width

    before intervention, immediately after, and 24 hours after intervention

Secondary Outcomes (2)

  • Atlas position

    before intervention, immediately after, and 24 hours after intervention

  • Craniovertebral angle

    before intervention, immediately after, and 24 hours after intervention

Study Arms (2)

Long axis thrust manipulation group

EXPERIMENTAL

A single long axis thrust manipulation C1-C3

Other: Thrust long-axis manipulation of C1-C2

Long axis thrust mobilization group

SHAM COMPARATOR

3 x 5 second Long axis traction hold of C1-C3

Other: Thrust long-axis manipulation of C1-C2

Interventions

Thrust long-axis manipulation of C1-C2OTHER

One thrust manipulation is provided in the thrust group. a 5 second long axis hold traction of C1-C2 was repeated 3 times in the mobilization group

Long axis thrust manipulation groupLong axis thrust mobilization group

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • read and understand English
  • no previous history of cervical spine surgery or traumatic cervical injury
  • no contraindications to cervical manual therapy

You may not qualify if:

  • any absolute contraindications to cervical manipulation
  • any other medical condition considered unsafe for manual therapy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Florida Gulf Coast University Marieb Hall 101

Fort Myers, Florida, 33965, United States

RECRUITING

MeSH Terms

Conditions

Headache

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Rob Sillevis, PhD

CONTACT

239-7454312rsillevis@fgcu.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
professor

Study Record Dates

First Submitted

July 21, 2026

First Posted

July 24, 2026

Study Start

May 1, 2025

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

July 24, 2026

Record last verified: 2026-07

Locations

US(1)