Comparison of Lee-Huang Point and Umbilical Entry for Laparoscopic Success in Endometrial Cancer Patients

NCT07725159 | Completed

• 1 other identifier: 2026/010.99/27/50
• Study Type: interventional
• Target: 202
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial compares Lee-Huang point entry with conventional umbilical entry for laparoscopic surgery in patients with endometrial cancer. The study aims to evaluate the success of abdominal entry, entry-related complications, operative outcomes, and perioperative safety. A total of 202 patients were randomized to either the Lee-Huang entry group or the umbilical entry group and underwent laparoscopic surgical staging. The findings are expected to provide evidence regarding the optimal primary entry technique for laparoscopic management of endometrial cancer.

Conditions

Endometrial Cancer

Keywords

Endometrial cancer; Laparoscopy; Lee-Huang point; Umbilical entry; Randomized controlled trial

Outcome Measures

Primary Outcomes (1)

• Successful laparoscopic abdominal entry

  Successful intraperitoneal access through the assigned entry site using direct trocar insertion without the need for conversion to another abdominal entry technique.

  During surgery

Secondary Outcomes (1)

• Entry-related complications

  During surgery

Study Arms (2)

Lee-Huang Point

EXPERIMENTAL

Laparoscopic abdominal entry using the Lee-Huang point

Procedure: Laparoscopic entry through the Lee-Huang point

Umbilical Entry

ACTIVE COMPARATOR

Standard laparoscopic abdominal entry through the umbilicus

Procedure: Standart umbilical laparoscopic entry

Interventions

Laparoscopic entry through the Lee-Huang point PROCEDURE

Initial laparoscopic abdominal entry was performed by direct tracar insertion through the Lee-Huang point

Lee-Huang Point

Standart umbilical laparoscopic entry PROCEDURE

Initial laparoscopic abdominal entry was performed by direct trocar insertion through the umbilicus.

Umbilical Entry

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female patients aged 18 years or older.
• Scheduled for elective laparoscopic gynecologic surgery.
• Eligible for laparoscopic abdominal entry through either the Lee-Huang point or the umbilical entry site.
• Provided written informed consent.

You may not qualify if:

• Pregnancy.
• Emergency surgery.
• Previous upper abdominal surgery precluding safe Lee-Huang point or umbilical entry.
• Contraindication to laparoscopy.
• Refusal or inability to provide informed consent.

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences Turkey, Kartal Dr. Lütfi Kırdar City Hospital

Istanbul, Istanbul, 34865, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Endometrial Neoplasms

Condition Hierarchy (Ancestors)

Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Murat Api, MD

  University of Health Sciences Turkey, Kartal Dr. Lütfi Kırdar City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Gynecologic Oncology Fellow

Study Record Dates

• First Submitted: July 21, 2026
• First Posted: July 24, 2026
• Study Start: April 28, 2024
• Primary Completion: April 28, 2026
• Study Completion: April 28, 2026
• Last Updated: July 27, 2026

Record last verified: 2026-07

Locations

TU (1)