Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies

NCT07725120 | Not Yet Recruiting

• 1 other identifier: 26Neuro04
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies. Clinical and electrophysiological data collected during routine care between January 2013 and July 2026 will be analyzed. Diagnostic performance will be assessed using receiver operating characteristic (ROC) curve analysis across predefined age groups to determine whether age-adjusted SRAR thresholds improve the differentiation between the two polyneuropathy phenotypes.

Conditions

Polyneuropathies; Electromyography; Diagnostic Techniques

Outcome Measures

Primary Outcomes (1)

• Diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR)

  To evaluate the diagnostic performance of the SRAR for differentiating length-dependent (LDN) from non-length-dependent (NLDN) peripheral sensory polyneuropathies according to age group, using receiver operating characteristic (ROC) curve analysis.

  Baseline (retrospective analysis of data collected between January 2013 and July 2026

Secondary Outcomes (2)

• Age-specific optimal SRAR diagnostic thresholds

  Baseline (retrospective analysis)

• Comparison of SRAR values between LDN and NLDN

  Baseline (retrospective analysis)

Study Arms (1)

Patients with peripheral sensory polyneuropathies

Other: Retrospective Medical Record Review

Interventions

Retrospective Medical Record Review OTHER

This observational study involves retrospective collection and analysis of routinely acquired clinical and electrophysiological data from approximately 180 patients with sensory polyneuropathy. Data extracted from medical records include demographic characteristics, clinical diagnosis, and nerve conduction study parameters, including sural and radial sensory nerve action potential amplitudes used to calculate the sural/radial amplitude ratio (SRAR). No additional diagnostic procedures, treatments, or study-specific assessments are performed. All data are obtained from standard clinical care.

Patients with peripheral sensory polyneuropathies

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with peripheral sensory polyneuropathies evaluated at the Peripheral Neuromuscular Rare Disease Reference Center of Nice University Hospital between January 2013 and July 2026. Patients will be classified into length-dependent or non-length-dependent phenotypes and stratified into predefined age groups for analysis.

You may qualify if:

• Adults aged 18 years or older.
• Diagnosis of peripheral sensory polyneuropathy.
• Classification as length-dependent (LDN) or non-length-dependent (NLDN) based on clinical and electrophysiological findings.
• Available nerve conduction study including sural and radial sensory nerve amplitudes allowing calculation of the SRAR.
• Evaluated at the Peripheral Neuromuscular Rare Disease Reference Center, Nice University Hospital, between January 2013 and July 2026.

You may not qualify if:

• Missing or incomplete clinical or electrophysiological data preventing SRAR calculation.
• Unclassifiable neuropathy phenotype.
• Technical factors affecting the reliability of nerve conduction studies.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CHU de Nice

Nice, Alpes Maritimes, 06000, France

Location

MeSH Terms

Conditions

Polyneuropathies

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases

Central Study Contacts

Angela Puma

CONTACT

0492035435; puma.ar@chu-nice.fr

Abderhmane Slioui

CONTACT

0492038953; slioui.a@chu-nice.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 21, 2026
• First Posted: July 24, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: July 24, 2026

Record last verified: 2026-07

Locations

FR (1)