Revascularization of Calcified Coronary Arteries
PICA
Percutaneous Coronary Intervention of Calcified Lesions and the Use of Artificial Intelligence to Predict Successful Outcome
1 other identifier
observational
100
1 country
1
Brief Summary
The primary aim of this study is to evaluate changes in absolute coronary flow and pressure before and after percutaneous coronary intervention in calcified lesions. The secondary aim is to use a machine learning model to predict the outcome of the intervention.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2025
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2025
CompletedFirst Submitted
Initial submission to the registry
August 20, 2025
CompletedFirst Posted
Study publicly available on registry
July 23, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 1, 2030
July 23, 2026
July 1, 2026
2.2 years
August 20, 2025
July 22, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Post-PCI FFR
FFR is measured after PCI is completed.
Immediately after the procedure
Interventions
The pressure and flow data will be integrated in a machine learning model
Eligibility Criteria
This a prospective clinical cohort study recruiting patients with stable coronary artery disease referred to invasive coronary angiography on clinical indication with angiographic calcium and eligible for PCI.
You may qualify if:
- Age \> 18 years
- Moderate (40-90 %) epicardial disease
- Vessel suitable for PCI and intracoronary imaging
- De novo-lesions
You may not qualify if:
- eGFR \< 40ml/min
- ACS \< 48 hours
- Patient without ability to provide informed consent
- Patient with left main stenosis
- Indication for coronary artery bypass grafting
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Aalborg University Hospital
Aalborg, Denmark
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
August 20, 2025
First Posted
July 23, 2026
Study Start
March 1, 2025
Primary Completion (Estimated)
May 1, 2027
Study Completion (Estimated)
May 1, 2030
Last Updated
July 23, 2026
Record last verified: 2026-07