DISE vs Muller's Maneuver in OSA Assessment

NCT07723417 | Completed

• 1 other identifier: MS.24.12.3032
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder caused by recurrent upper airway collapse during sleep. Accurate identification of the site and pattern of upper airway obstruction is essential for selecting the appropriate treatment. Müller's maneuver has been widely used as an office-based assessment tool; however, it has limitations in reproducing natural sleep conditions. Drug-Induced Sleep Endoscopy (DISE) allows dynamic visualization of the upper airway under sedated conditions and may provide more accurate information about the level and pattern of airway collapse. This study aims to compare the findings of DISE with Müller's maneuver in patients with obstructive sleep apnea and to evaluate the diagnostic value of both techniques in upper airway assessment.

Conditions

Obstructive Sleep Apnea

Outcome Measures

Primary Outcomes (1)

• Agreement between Drug-Induced Sleep Endoscopy (DISE) using the VOTE cassification and Müller's Maneuver in assesment of OSA.

  Agreement between Drug-Induced Sleep Endoscopy (DISE) findings, assessed using the VOTE classification, and Müller's maneuver findings in identifying the site, degree, and pattern of upper airway collapse in patients with obstructive sleep apnea. Agreement will be quantified using Cohen's kappa coefficient.

  Baseline (during the same study visit)

Study Arms (1)

Single Study Arm

EXPERIMENTAL

Participants with obstructive sleep apnea will undergo awake flexible endoscopy with Müller's maneuver followed by Drug-Induced Sleep Endoscopy (DISE). The findings of both procedures will be compared to assess the site, degree, and pattern of upper airway obstruction.

Procedure: Drug-Induced Sleep Endoscopy (DISE)

Interventions

Drug-Induced Sleep Endoscopy (DISE) PROCEDURE

Drug-induced sleep endoscopy performed under sedation to evaluate the site, degree, and pattern of upper airway collapse in patients with obstructive sleep apnea.

Single Study Arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \> 18 years old.
• Diagnosed as OSAS according to polysomnography and AASM (June 2023).
• Body mass index \< 40

You may not qualify if:

• Age \< 18 years.
• Central sleep apnea.
• Hypoventilation syndromes.
• Cardiac arrhythmias.
• ischemic heart disease.
• Heart failure.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoua University Hospital

Al Mansurah, Dakahlia Governorate, 35511, Egypt

Location

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Lucy Soliman, Professor

  Chest Medicine Department, Faculty of Medicine, Mansoura University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 17, 2026
• First Posted: July 23, 2026
• Study Start: February 12, 2025
• Primary Completion: September 10, 2025
• Study Completion: March 15, 2026
• Last Updated: July 23, 2026

Record last verified: 2026-07

Locations

EG (1)