Abnormality of the Central Canal of the Spinal Cord in Syringomyelia in a Patient With a Basal Skull Malformation

NCT07720206 | Not Yet Recruiting

• 1 other identifier: CHUBX 2026/003
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to analyze the association between a deformity of the cranial portion of the central spinal canal and syringomyelia in patients with a Chiari-type malformation of the craniocervical junction. The investigators hypothesize that Chiari malformation, defined by the herniation of the cerebellar tonsils through the foramen magnum, may be responsible for a deformation of the cranial portion of the central spinal canal, and that this deformation is associated with the presence of syringomyelia in patients with this malformation.

Conditions

Chiari Malformation Type I; Syringomyelia

Keywords

Chiari malformation; spinal cord; central canal; MR; syringomyelia

Outcome Measures

Primary Outcomes (1)

• Deformation of the central canal of the spinal cord

  The central canal deformation index of the spinal cord, calculated based on the angle of the curves and the length of each segment between two curves.

  At inclusion (D0)

Secondary Outcomes (5)

• Protrusion of the cerebellar tonsils

  at inclusion (day 0)

• Presence and dimensions of syringomyelia

  At inclusion (day 0)

• Distance between the obex and the foramen magnum

  At inclusion (Day 0)

• Diffusion MRI parameter (1)

  At inclusion (Day 0)

• Diffusion MRI parameter (2)

  At inclusion (Day 0)

Study Arms (2)

Patients with Chiari malformation with associated syringomyelia

EXPERIMENTAL

Procedure: MRI

Patients with Chiari malformation without associated syringomyelia

EXPERIMENTAL

Procedure: MRI

Interventions

MRI PROCEDURE

Magnetic Resonance Imaging (MRI) using T1, T2, White-Matter nulled (WMn), and diffusion sequences

Patients with Chiari malformation with associated syringomyelia; Patients with Chiari malformation without associated syringomyelia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients being treated for Chiari malformation or syringomyelia at Bordeaux University Hospital
• Patients admitted for an initial surgical consultation regarding Chiari malformation with or without syringomyelia at Bordeaux University Hospital
• Individuals enrolled in or covered by a social security program.
• Free, informed, and express consent (confirmed in writing) (no later than the day of enrollment and prior to any examination required by the study).

You may not qualify if:

• Pregnant or breastfeeding patients
• Contraindications to MRI
• Individuals deprived of their liberty by judicial or administrative order,
• Adults subject to legal protective measures (guardianship, conservatorship, judicial protection).
• Patients who have previously undergone surgery for a Chiari malformation or a posterior fossa malformation

Sponsors & Collaborators

• University Hospital, Bordeaux: lead
• University of Bordeaux: collaborator

Study Sites (1)

Bordeaux university hospital

Bordeaux, France

Location

MeSH Terms

Conditions

Arnold-Chiari Malformation; Syringomyelia

Condition Hierarchy (Ancestors)

Neural Tube Defects; Nervous System Malformations; Nervous System Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Spinal Cord Diseases; Central Nervous System Diseases

Central Study Contacts

Jean-Rodolphe VIGNES, Pr

CONTACT

05 57 95 54 43; jean-rodolphe.vignes@chu-bordeaux.fr

Paul ROBLOT, Dr

CONTACT

05 56 79 55 43; paul.roblot@chu-bordeaux.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: single-center, prospective, cross-sectional, descriptive study

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: July 22, 2026
• Study Start (Estimated): September 30, 2026
• Primary Completion (Estimated): September 30, 2029
• Study Completion (Estimated): September 30, 2029
• Last Updated: July 22, 2026

Record last verified: 2026-07

Locations

FR (1)