NCT07720128|Not Yet RecruitingDMC
Advanced HIV Re-engagement in Care
ARC
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ARC
Sponsor study identifier
interventional
724
1 country
1
Study Start
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
May 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Adults who are hospitalized in Lusaka, Zambia, and found to have advanced HIV disease will be enrolled and randomly assigned to receive the ARC intervention or standard of care. All participants will then be followed through the end of the hospitalization and for up to 1 year after discharge from hospital.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 17, 2026
Actual (reported)July 22, 2026
Actual (reported)May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
May 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
August 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
All-cause mortality
Mortality will be ascertained as follows. All participants will receive monthly phone check-ins and if they don't respond a study staff member will trace their whereabouts in the community. This process will lead investigators to find out about deaths. In addition, investigators may be informed by a hospital staff member where a participant was admitted and died.
Enrollment to up to 1 year
HIV viral suppression
Enrollment, 3 months and 1 year
Retention in HIV care
At 3 months and 1 year
Medication possession ratio
At 3 months and 12 months
In this trial arm, participants will be provided with the ARC intervention package.
In this arm, participants will be managed according to the standard of care.
ARC is a multi-component package of support delivered primarily by a community health worker. It is oriented towards the medical and psychosocial and sociobehavioral challenges of advanced HIV disease and hospitalization.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
University Teaching Hospital
Lusaka, Zambia
Bwalya C, Stoebenau K, Muchanga G, Mwale M, Maambo C, Banda S, Halwiindi P, Mwango LK, Baumhart C, Mbewe N, Mwitumwa M, Mulenga P, Charurat M, Mutale W, Vinikoor MJ, Claassen CW. Hospitalized with HIV in Zambia: individual and system factors driving the high burden of admissions and post-discharge mortality in the era of HIV epidemic control. AIDS Res Ther. 2025 Feb 24;22(1):22. doi: 10.1186/s12981-024-00689-2.
Mbewe N, Vinikoor MJ, Fwoloshi S, Mwitumwa M, Lakhi S, Sivile S, Yavatkar M, Lindsay B, Stafford K, Hachaambwa L, Mulenga L, Claassen CW. Advanced HIV disease management practices within inpatient medicine units at a referral hospital in Zambia: a retrospective chart review. AIDS Res Ther. 2022 Feb 22;19(1):10. doi: 10.1186/s12981-022-00433-8.
Lottie Hachaambwa, MBChB
Ciheb Zambia
Cassidy Claassen, MD
University of Maryland, Baltimore
Michael J Vinikoor, MD
University of Alabama at Birmingham
First Submitted
July 17, 2026
Contact the study team to confirm eligibility.
Ford N, Ehrenkranz P, Jarvis J. Advanced HIV as a Neglected Disease. N Engl J Med. 2024 Feb 8;390(6):487-489. doi: 10.1056/NEJMp2313777. Epub 2024 Feb 3. No abstract available.
First Posted
July 22, 2026
Study Start
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
May 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
July 23, 2026
Record last verified: 2026-07
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Source: ClinicalTrials.gov.
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