Bipolar Enucleation of the Prostate Versus Bipolar TURP

NCT07718256 | Completed DMC

• 1 other identifier: FMASU MS 56/2026
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large prostates above 80 gm.

Conditions

Benign Prostate Hypertrophy(BPH)

Outcome Measures

Primary Outcomes (3)

• volume of residual prostatic adenoma

  measurement of volume of residual prostatic adenoma post bipolar TURP and BEEP was done by pelvi-abdominal ultrasound

  one month postoperative

• change in international prostate symptoms score

  The international prostate symptoms score is a patient-completed questionnaire for standardized assessment of lower urinary tract symptoms (LUTS). It includes seven questions that evaluate the following urinary symptoms: * Weak urinary stream (0 : 5) * Incomplete bladder emptying (0 : 5) * Straining during urination (0 : 5) * Intermittent urine flow (0 : 5) * Increased urinary frequency (0 : 5) * Urgency (0 : 5) * Nocturia (0 : 5) Grade 1 (score = 0 - 7) : Mild LUTS Grade 2 (score = 8 - 19) : Moderate LUTS Grade 3 (score = 20 - 35) : Severe LUTS

  pre-operative, one, three, six and twelve months postoperative

• change in maximum urine flow rate(Q max)

  Maximum urine flow rate was evaluated by Uroflowmetry

  pre-operative, 1, 3, 6 and 12 months postoperative

Secondary Outcomes (2)

• change in post voiding residual urine

  pre-operative, 1, 3, 6 and 12 months postoperative

• operation time

  during operation

Study Arms (2)

bipolar TURP

ACTIVE COMPARATOR

transurethral resection of the prostate by bipolar current

Procedure: bTURP

BEEP

ACTIVE COMPARATOR

endoscopic enucleation of the prostate by bipolar current

Procedure: BEEP

Interventions

bTURP PROCEDURE

transurethral resection of the prostate by bipolar current

Also known as: TURIS

bipolar TURP

BEEP PROCEDURE

endoscopic enucleation of the prostate by bipolar current

Also known as: TUEP

BEEP

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All male patients above the age of 40 years who presented to the urology clinic in Ain Shams university hospitals with BPH with prostate size 80 - 120 g and have any of the following criteria:
• Voiding symptoms that are poorly responsive to medical treatment (IPSS more than 18 and Qmax less than 15 ml/sec)
• Persistent or recurrent attacks of urine retention due to BPH.
• Large bladder stones from BPH.
• Recurrent UTI due to BPH.
• Severe gross hematuria from BPH.

You may not qualify if:

• Patients with untreated or active UTI.
• Previous pelvic radiation or pelvicl trauma.
• Patients with anesthesia contraindications such as uncontrolled diabetes mellitus, severe coagulation disorders and severe cardiac diseases.
• Known or suspected neurogenic bladder.
• Urethral stricture or urethral cancer.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams university hospitals

Cairo, Cairo Governorate, 11566, Egypt

Location

MeSH Terms

Conditions

Prostatic Hyperplasia

Condition Hierarchy (Ancestors)

Prostatic Diseases; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: A statistician randomized the eligible patients using block randomization with a block size of 8. Allocation concealment was achieved using sequentially numbered opaque sealed envelopes. The participants were blinded to the assigned type of intervention at the time of surgery. Outcome assessors also were blinded, whereas surgeons were not blinded.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: one group had undergone bipolar TURP and the other group had undergone bipolar enucleation of the prostate

Study Record Dates

• First Submitted: July 17, 2026
• First Posted: July 21, 2026
• Study Start: July 1, 2025
• Primary Completion: June 30, 2026
• Study Completion: July 14, 2026
• Last Updated: July 31, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)