MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI

NCT07717073 | Active Not Recruiting

• 1 other identifier: 2025-A01310-49
• Study Type: observational
• Target: 602
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI. This is a study linked to the MyocarditIRM cohort, designed to collect genetic test results obtained as part of routine clinical care.

Conditions

Acute Myocarditis

Keywords

acute myocarditis; pathogenic genetic variants; dilated cardiomyopathies; cardiomyopathies; arrhythmogenic

Outcome Measures

Primary Outcomes (1)

• Prevalence and characterization of genetic variants (genes involved and ACMG classification) in patients with MRI-confirmed acute myocarditis.

  From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Secondary Outcomes (4)

• All-cause mortality

  From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

• Cardiovascular mortality

  From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

• Major adverse cardiovascular events

  During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)

• Cardiac MRI sequelae

  During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode

Study Arms (1)

Patients included in Cohort MyocarditIRM with genetic testing results available

Retrospective observational study using data extracted from the hospital data warehouse and linked to the French National Health Data System (SNDS). Genetic analyses were performed as part of routine clinical care and were retrospectively collected for research purposes. No study-specific intervention was performed.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients included in myocarditIRM who have genetic data

You may qualify if:

• Patient enrolled in MyocarditIRM
• Patient who has undergone genetic testing

You may not qualify if:

• Patient who has objected to the reuse of their data

Sponsors & Collaborators

• French Cardiology Society: lead

Study Sites (1)

CHU de Poitiers

Poitiers, France, 86000, France

Location

MeSH Terms

Conditions

Cardiomyopathy, Dilated; Cardiomyopathies

Condition Hierarchy (Ancestors)

Cardiomegaly; Heart Diseases; Cardiovascular Diseases; Laminopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 11, 2026
• First Posted: July 21, 2026
• Study Start: July 15, 2025
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: July 21, 2026

Record last verified: 2026-07

Locations

FR (1)