Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients

NCT07713030 | Recruiting

• 1 other identifier: REC/RCR & AHS/25/0302
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups; group A and group B. Group A will be assigned high intensity interval training and group B will be assigned to continuous training.

Conditions

PreDiabetes; Pre Diabetes; Prediabetic State

Keywords

BMI; vo2 Max; glycemic control; Physical Activity; High-Intensity Interval Training

Outcome Measures

Primary Outcomes (5)

• fasting blood glucose

  Participants were instructed to fast overnight for 8 to 12 hours. FBG was measured using an automated glucose analyzer

  12 weeks

• Forced Vital Capacity

  Spirometry using devices like a digital spirometry will be used. Forced Vital Capacity (FVC) will be measured in liters (L) using spirometry. FVC represents the maximum volume of air that can be forcefully exhaled after a maximal inspiration.

  12 weeks

• Forced Expiratory Volume in One Second

  Forced Expiratory Volume in One Second (FEV₁) will be measured in liters (L) using spirometry. FEV₁ represents the volume of air exhaled during the first second of a forced expiratory maneuver.

  12 weeks

• FEV₁/FVC ratio

  The FEV₁/FVC ratio will be expressed as a percentage (%) and calculated from spirometric measurements to assess the degree of airflow limitation.

  12 weeks

• HbA1c

  HbA1c was assesed through high performance liquid chromatography

  12 weeks

Secondary Outcomes (3)

• Body mass index (BMI)

  12 weeks

• IPAQ (short form) questionnaire

  12 weeks

• Maximal Oxygen Uptake (VO₂max)

  12 weeks

Study Arms (2)

High-Intensity Interval Training

ACTIVE COMPARATOR

High intensity interval training is a training method that involves repeated bouts of short duration, highintensity exercise typicallyb performed at ≥ 85 -95% of maximal heart rate or vo2 max interspersed with period of low intensity recovery or complete rest.

Behavioral: High-Intensity Interval Training

Continuous Endurance Training

ACTIVE COMPARATOR

Continuous endurance training also called moderate intensity continuous training involves sustained exercise at a moderate and steady intensity typically 60to 75% of vo2 max or maximal heart rate performed for a continuous duration without rest intervals

Behavioral: Continuous Endurance Training

Interventions

High-Intensity Interval Training BEHAVIORAL

5 minutes warm up including walk * 30s fast stairs climbing * 60s slow walk down * Repeat 5 to 6 rounds * 5 minute stretching or slow walk (cool down)

High-Intensity Interval Training

Continuous Endurance Training BEHAVIORAL

5 to 10 minute walking (warm up ) * 25 to 30minutes at 60 to 70 %continuous training * Continuous walk for 15 to 20 minutes. * 5 to 10 minutes stretching (cool down)

Continuous Endurance Training

Eligibility Criteria

• Age: 35 Years - 54 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Sedentary lifestyle (Individuals reporting minimal structured physical activity e.g., \<30 minutes of exercise per week) .
• Stable Medical Condition (No history of significant cardiovascular events, uncontrolled hypertension, or other major comorbidities).
• Stable Body Weight (Stable body weight with changes less than 3 kg in the past 6 months).

You may not qualify if:

• uncontrolled hypertension
• history of heart disease
• myocardial infarction
• stroke
• Use of Specific Medications (Current use of insulin or other medications affecting glucose metabolism or exercise response)
• Severe Obesity (Individuals with a BMI ≥ 40 kg/m)
• High fasting blood glucose (Fasting blood glucose of \>100mg.dl-1)
• Previous history of respiratory problems
• Smoking

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Rihpah international university Lahore campus

Lahore, Punjab Province, 40100, Pakistan

RECRUITING

MeSH Terms

Conditions

Prediabetic State; Glucose Intolerance; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hyperglycemia; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Arjumand Bano, MS

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Muhammad Iqbal Tariq, Phd

CONTACT

333826752; iqbal.tariq@riphah.edu.pk

Misdaq Batool, MS PT

CONTACT

03466584498; misdaaqbatool@yahoo.com.ph

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: July 20, 2026
• Study Start: May 1, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: July 20, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)