ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis

NCT07712835 | Completed

• 1 other identifier: STUDY00001444
• Study Type: observational
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under 18 years old with an underlying oncologic diagnosis and/or hematopoietic stem cell transplant on Extracorporeal membrane oxygenation (ECMO). In a small multicenter cohort, the comparative analysis evaluated survival outcomes in this population with respiratory failure in the presence and absence of ECMO. Children's Mercy Kansas City served as the ECMO cohort; Cincinnati Children's Hospital Medical Center served as the matched non-ECMO cohort.

Conditions

ECMO Outcomes; Respiratory Failure (Pediatric Patients); Malignancies, Hematologic; Solid Tumor Malignancies; Hematopoetic Stem Cell Transplant

Keywords

Extracorporeal membrane oxygenation; Respiratory failure; Hematopoietic stem cell transplant; Pediatric Intensive Care Unit; Neoplasms

Outcome Measures

Primary Outcomes (1)

• Comparison of survival rates in pediatric patients with an underlying malignancy and/ or hematopoietic stem cell transplant in the presence and absence of ECMO support

  Admission until hospital discharge, average of 46 days

Study Arms (2)

ECMO Cohort

Eleven patients under 18 years old with an underlying oncologic diagnosis and/or hematopoietic stem cell transplant received Extracorporeal membrane oxygenation (ECMO) as a rescue therapy for respiratory failure. Children's Mercy Hospital served as the ECMO cohort.

Other: Extracorporeal membrane oxygenation (ECMO)

Non-ECMO Cohort

Eleven patients under 18 years old with an underlying oncologic diagnosis and/or hematopoietic stem cell transplant received conventional therapies for management of respiratory failure. Cincinnati Children's Hospital Medical Center served as the non-ECMO cohort.

Interventions

Extracorporeal membrane oxygenation (ECMO) OTHER

ECMO utilization in patient with malignancy and/or history of hematopoietic stem cell transplant.

ECMO Cohort

Eligibility Criteria

• Age: 4 Weeks - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients, under the age of 18, admitted to a tertiary care pediatric intensive care unit for management of respiratory failure warranting mechanical ventilation. Beyond this, only pediatric patients with an underlying oncologic and/or hematopoietic stem cell transplant were included in the study.

You may qualify if:

• Less than 18 years old
• Admitted to the PICU for respiratory failure (2015-2023)
• Underlying oncologic diagnosis and/or hematopoietic stem cell transplant
• Mechanical ventilation

Sponsors & Collaborators

• Children's Mercy Hospital Kansas City: lead
• Children's Hospital Medical Center, Cincinnati: collaborator

MeSH Terms

Conditions

Respiratory Insufficiency; Hematologic Neoplasms; Neoplasms

Interventions

Extracorporeal Membrane Oxygenation

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Neoplasms by Site; Hematologic Diseases; Hemic and Lymphatic Diseases

Intervention Hierarchy (Ancestors)

Respiratory Therapy; Therapeutics; Extracorporeal Circulation; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Pediatric Intensivist

Study Record Dates

• First Submitted: July 10, 2026
• First Posted: July 20, 2026
• Study Start: February 1, 2015
• Primary Completion: December 1, 2024
• Study Completion: April 1, 2025
• Last Updated: July 20, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share