Titanium-Prepared Platelet-Rich Fibrin for Extraction Socket Healing

NCT07712497 | Completed

• 1 other identifier: ESOGU-TPRF-2023-01
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Alveolar ridge preservation after tooth extraction is important for maintaining bone volume and facilitating future implant placement. Titanium-prepared platelet-rich fibrin (T-PRF) is an autologous platelet concentrate that may enhance soft and hard tissue healing through the sustained release of growth factors. However, clinical evidence regarding its effect on socket healing remains limited. The aim of this prospective randomized controlled clinical trial is to evaluate the effect of T-PRF on alveolar socket healing following tooth extraction. Participants requiring tooth extraction and subsequent implant placement are randomly assigned to either a T-PRF group or a spontaneous healing (control) group. Cone-beam computed tomography (CBCT) is used to evaluate socket healing volumetrically. The primary outcome is the percentage of socket fill and residual non-ossified socket volume after 3 months. Secondary outcomes include baseline socket volume and postoperative clinical healing. The findings of this study are expected to provide evidence regarding the effectiveness of T-PRF in enhancing alveolar socket healing and preserving ridge dimensions before implant placement.

Conditions

TEETH EXTRACTION

Keywords

Titanium-Prepared Platelet-Rich Fibrin, Alveolar Ridge Preservation, Cone-Beam Computed Tomography,

Outcome Measures

Primary Outcomes (2)

• Percentage of Socket Fill

  Percentage of socket fill calculated using CBCT-based volumetric analysis by comparing the baseline socket volume with the residual non-ossified socket volume after healing.

  3 months after tooth extraction

• Percentage of Socket Fill

  Percentage of socket fill calculated from CBCT-based volumetric measurements by comparing baseline socket volume with the residual non-ossified socket volume after 3 months.

  3 months after tooth extraction

Study Arms (2)

T-PRF Group

EXPERIMENTAL

Participants underwent atraumatic tooth extraction followed by placement of autologous titanium-prepared platelet-rich fibrin (T-PRF) into the extraction socket. Standard postoperative care was provided, and healing was evaluated over a 3-month follow-up period.

Biological: Titanium-Prepared Platelet-Rich Fibrin (T-PRF)

Control Group

NO INTERVENTION

Participants underwent atraumatic tooth extraction followed by placement of autologous titanium-prepared platelet-rich fibrin (T-PRF) into the extraction socket. Standard postoperative care was provided, and healing was evaluated during a 3-month follow-up period.

Interventions

Titanium-Prepared Platelet-Rich Fibrin (T-PRF) BIOLOGICAL

Autologous titanium-prepared platelet-rich fibrin (T-PRF) was prepared from the participant's venous blood collected into sterile titanium tubes without anticoagulant and centrifuged immediately after blood collection. The resulting fibrin clot was separated from the red blood cell layer, compressed into a membrane, and placed into the extraction socket immediately after atraumatic tooth extraction. The socket was then stabilized with sutures according to the study protocol.

Also known as: T-PRF

T-PRF Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 to 65 years.
• Systemically healthy individuals.
• Indication for tooth extraction followed by implant placement.
• Adequate bone volume for future implant placement without the need for advanced augmentation procedures.
• Good oral hygiene (Plaque Index ≤1.5)
• Ability and willingness to provide written informed consent.

You may not qualify if:

• Current smokers.
• Pregnant or breastfeeding women.
• Uncontrolled systemic disease or diabetes mellitus.
• Use of medications known to affect bone metabolism.
• History of head and neck radiotherapy or chemotherapy.
• Acute infection, periapical lesions, alveolar bone pathology, or socket defects at the extraction site.
• Severe periodontal destruction requiring extensive augmentation procedures.
• Inability or unwillingness to attend scheduled follow-up visits.

Sponsors & Collaborators

• Eskisehir Osmangazi University: lead

Study Sites (1)

Department of Periodontology, Faculty of Dentistry, Eskişehir Osmangazi University

Eskişehir, 26140, Turkey (Türkiye)

Location

Study Officials

• hakan özdemir, proffesor

  Eskişehir Osmangazi University, Faculty of Dentistry, Department of Periodontology

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Radiographic volumetric measurements were performed by an outcome assessor who was blinded to the treatment allocation. No other study personnel were masked.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Model Details: Participants were randomly assigned to one of two parallel groups. The intervention group received titanium-prepared platelet-rich fibrin (T-PRF) following atraumatic tooth extraction, whereas the control group underwent spontaneous socket healing without any socket preservation material. Clinical and volumetric radiographic outcomes were assessed over a 3-month follow-up period.

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 17, 2026
• Study Start: March 1, 2023
• Primary Completion: December 29, 2023
• Study Completion: December 29, 2023
• Last Updated: July 17, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Beginning 6 months after publication and ending 5 years after publication.
• Access Criteria: De-identified individual participant data and the study protocol and statistical analysis plan will be available to qualified researchers who submit a methodologically sound research proposal. Requests should be directed to the corresponding author. Access will be granted after scientific review and approval of the proposal and execution of an appropriate data sharing agreement, where applicable.

Locations

TU (1)