Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis

NCT07709026 | Completed

• 1 other identifier: 2022/311
• Study Type: observational
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA). Patients who receive a corticosteroid injection into the knee joint as part of their routine medical treatment will be monitored prospectively. The study aims to assess changes in range of motion, functional status, and pain levels before the injection and during the early follow-up period after the procedure. This will help healthcare providers better understand the immediate benefits and functional outcomes of this treatment in youth sports and daily physical activities.

Conditions

Juvenile Idiopathic Arthritis (JIA)

Keywords

Balance; gait; muscle strength; physical function

Outcome Measures

Primary Outcomes (1)

• Change from Baseline in Pain Intensity

  Pain intensity assessed at rest and during physical activity using a standard assessment scale.

  Baseline (T0), 2 weeks (T1), and 2 months (T2) post-injection

Interventions

Intra-articular Corticosteroid Injection DRUG

Patients diagnosed with juvenile idiopathic arthritis (JIA) underwent a routine clinical knee intra-articular corticosteroid injection (IACI) due to active knee involvement. Clinical, functional, and physical strength assessments were performed prospectively at three specific time points: before the injection (baseline, T0), at 2 weeks post-treatment (T1), and at 2 months post-treatment (T2) to evaluate short-term outcomes.

Eligibility Criteria

• Age: 8 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of pediatric patients diagnosed with Juvenile Idiopathic Arthritis (JIA) who present with active unilateral or bilateral knee joint involvement. Participants include both newly diagnosed individuals and those under regular follow-up at a tertiary medical center's outpatient clinic, all of whom required clinical knee intra-articular corticosteroid injection (IACI) as part of their routine medical management.

You may qualify if:

• Patients diagnosed with juvenile idiopathic arthritis (JIA) according to standard criteria (arthritis with onset before the age of 16 years and duration longer than 6 weeks with no other identifiable cause).
• Having unilateral or bilateral active knee joint arthritis.
• Undergoing knee intra-articular corticosteroid injection (IACI) for the active knee joint involvement.
• Provision of written informed consent by both patients and their caregivers.

You may not qualify if:

• Presence of other chronic rheumatological diseases.
• Initiation or discontinuation of systemic steroids, conventional disease-modifying anti-rheumatic drugs (DMARDs) (e.g., methotrexate, sulfasalazine), or biologic DMARDs (e.g., inhibitors of TNF, IL-1, or IL-6) within the 3 months before knee IACI and during the follow-up period.
• History of severe adverse reactions to steroids.
• Presence of neurological diseases.
• History of lower extremity surgery.
• Missing data.

Sponsors & Collaborators

• Necmettin Erbakan University: lead

Study Sites (1)

Necmettin Erbakan University, Faculty of Health Sciences

Konya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Arthritis, Juvenile

Interventions

Adrenal Cortex Hormones

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: July 11, 2026
• First Posted: July 16, 2026
• Study Start: November 15, 2022
• Primary Completion: August 15, 2023
• Study Completion: August 15, 2023
• Last Updated: July 16, 2026

Record last verified: 2026-07

Locations

TU (1)