NCT07708415

Brief Summary

Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,000

participants targeted

Target at P75+ for all trials

Timeline
5mo left

Started Jul 2026

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress17%
Jul 2026Dec 2026

Study Start

First participant enrolled

July 1, 2026

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

July 3, 2026

Completed
13 days until next milestone

First Posted

Study publicly available on registry

July 16, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

July 16, 2026

Status Verified

July 1, 2026

Enrollment Period

6 months

First QC Date

July 3, 2026

Last Update Submit

July 10, 2026

Conditions

PolypsColorectal Cancer

Keywords

Colorectal CancerPolyp recurrencePathomicsPrognostic model

Outcome Measures

Primary Outcomes (2)

  • Adenoma recurrence after colorectal surgery

    Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence

    Postoperative；follow up till 5 years

  • Colitisafter colorectal surgery

    Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence

    Postoperative；follow up till 5 years

Study Arms (1)

Postoperative endoscopic polyp recurrence of colorectal cancer

Corhort of colorectal cancer patients undergoing colonoscopy follow-up after surgery

Procedure: Endoscopic polypectomy

Interventions

Endoscopic polypectomyPROCEDURE

Endoscopic polypectomy

Postoperative endoscopic polyp recurrence of colorectal cancer

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects.After the completion of the prediction model construction, we will include 3-5 external queues for external validation.

You may qualify if:

  • Diagnosed with colon cancer through histopathological examination ; Undergoing radical R0 resection ； Complete Colonoscopy follow-up after surgery less than 12 months.

You may not qualify if:

  • With adenomatous polyposis , Lynch syndrome and Peutz-Jeghers syndrome； Combined inflammatory bowel disease; Polyp were present before surgery and have not been completely removed； With distant metastasis or local recurrence； Clinical data is missing and can not be analyzed.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Gansu provincial hospital

Lanzhou, Gansu, 730000, China

Location

Related Publications (4)

  • Galjart B, Hoppener DJ, Aerts JGJV, Bangma CH, Verhoef C, Grunhagen DJ. Follow-up strategy and survival for five common cancers: A meta-analysis. Eur J Cancer. 2022 Oct;174:185-199. doi: 10.1016/j.ejca.2022.07.025. Epub 2022 Aug 27.

    PMID: 36037595BACKGROUND

  • IJspeert JEG, Bretthauer M, Jover R, Dekker E; Dutch colonoscopy surveillance working group. Balancing benefit and burden: rethinking post-polypectomy colonoscopy surveillance strategies. Lancet Gastroenterol Hepatol. 2026 Jun 19:S2468-1253(26)00128-7. doi: 10.1016/S2468-1253(26)00128-7. Online ahead of print.

    PMID: 42320508RESULT

  • Ebert MP, Reichermeier S, Klug L, Lynen Jansen P, Pox C. Clinical Practice Guideline: Colorectal Cancer-Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care. Dtsch Arztebl Int. 2025 Dec 26;122(26):729-734. doi: 10.3238/arztebl.m2025.0196. Epub 2025 Dec 26.

    PMID: 41195479RESULT

  • Laven-Law G, Symonds EL, Simpson K, Coats M, De Silva M, Hollington P, Cock C, Wassie MM. Risk of Advanced Colorectal Neoplasia at Follow-up Colonoscopy After Synchronous Adenoma and Clinically Significant Serrated Polyp. Clin Gastroenterol Hepatol. 2026 Feb;24(2):544-553. doi: 10.1016/j.cgh.2025.07.023. Epub 2025 Aug 5.

    PMID: 40774589RESULT

MeSH Terms

Conditions

Colorectal NeoplasmsPolyps

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
M.D Endoscopic diagnosis and treatment center, Gansu provincial hospital, Lanzhou, Gansu, China

Study Record Dates

First Submitted

July 3, 2026

First Posted

July 16, 2026

Study Start

July 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

July 16, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)