Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)

NCT07707830 | Not Yet Recruiting

• 1 other identifier: HYPOMORPH-2026
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This hospital-based observational cross-sectional study aims to investigate the morphometric characteristics of internal organs and the morphofunctional status of the musculoskeletal system in adult patients with previously diagnosed hypothyroidism. The study will evaluate ultrasonographic morphometric characteristics of the liver, pancreas, and kidneys, as well as anthropometric and functional characteristics of the musculoskeletal system. Associations between these outcomes and clinical characteristics, anthropometric parameters, physical activity, and laboratory findings will also be assessed. The study is expected to identify accessible clinical, anthropometric, and functional markers associated with morphometric and musculoskeletal changes in patients with hypothyroidism, thereby improving risk assessment and early detection of systemic involvement.

Conditions

Hypothyroidism

Keywords

Hypothyroidism; Ultrasonography; Morphometry; Liver; Pancreas; Kidney; Musculoskeletal System; Anthropometry; Physical Function; Cross-Sectional Study; Physical Activity; Physical Inactivity

Outcome Measures

Primary Outcomes (4)

• Liver Longitudinal Diameter

  The longitudinal diameter of the liver will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in centimeters (cm).

  Baseline

• Pancreatic Head Thickness

  The anteroposterior thickness of the pancreatic head will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in millimeters (mm).

  Baseline

• Kidney Length

  The longitudinal length of each kidney will be measured by ultrasonography according to the standardized study protocol. Measurements will be recorded in millimeters (mm).

  Baseline

• Handgrip Strength

  Muscle strength will be assessed using a calibrated handgrip dynamometer. Maximum grip strength will be recorded in kilograms (kg). Higher values indicate greater muscle strength.

  Baseline

Secondary Outcomes (4)

• Five Times Sit-to-Stand Test

  Baseline

• Body Mass Index

  Baseline

• Waist Circumference

  Baseline

• Calf Circumference

  Baseline

Study Arms (1)

Patients With Hypothyroidism

Adult patients with a previously established diagnosis of hypothyroidism who will undergo clinical examination, anthropometric assessment, ultrasonographic evaluation of the liver, pancreas and kidneys, functional assessment of the musculoskeletal system, and laboratory testing according to the study protocol.

Diagnostic Test: Comprehensive Morphometric and Functional Assessment

Interventions

Comprehensive Morphometric and Functional Assessment DIAGNOSTIC_TEST

Participants will undergo a standardized diagnostic assessment including clinical evaluation, anthropometric measurements, ultrasonographic examination of the liver, pancreas, and kidneys, functional

Patients With Hypothyroidism

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with a previously established diagnosis of hypothyroidism receiving routine medical care at participating healthcare institutions.

You may qualify if:

• Adults aged 18-59 years.
• Previously established diagnosis of hypothyroidism.
• Receiving routine outpatient or inpatient care at participating healthcare institutions.
• Ability to undergo ultrasonographic, anthropometric, and functional assessments.
• Provision of written informed consent.

You may not qualify if:

• Pregnancy or lactation.
• History of thyroid malignancy.
• Acute infectious or inflammatory disease at the time of enrollment.
• Severe decompensated cardiovascular, hepatic, or renal disease preventing study procedures.
• Neurological or musculoskeletal disorders that preclude functional testing.
• Refusal or inability to provide informed consent.
• Incomplete clinical or laboratory data.

Sponsors & Collaborators

• Andijan State Medical Institute: lead

Study Sites (1)

Andijan State Medical Institute

Andijan, 170127, Uzbekistan

Location

MeSH Terms

Conditions

Hypothyroidism; Motor Activity; Sedentary Behavior

Condition Hierarchy (Ancestors)

Thyroid Diseases; Endocrine System Diseases; Behavior

Central Study Contacts

Abdukhalim Kh. Abdurakhimov, PhD

CONTACT

+998941010091; abduhalim@adti.uz

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 16, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2028
• Last Updated: July 16, 2026

Record last verified: 2026-07

Locations

UZ (1)