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Sponsor study identifier
interventional
59
1 country
1
Study Start
May 18, 2026
Actual (reported)Primary Completion
June 15, 2026
Actual (reported)Study Completion
July 7, 2026
Actual (reported)Dental fluorosis is a developmental enamel defect characterized by discoloration and altered enamel appearance, which may negatively affect dental esthetics and patient satisfaction. Conservative treatment approaches, including enamel microabrasion and minimally invasive chemical treatments, have been proposed to improve the appearance of affected teeth while preserving tooth structure. However, evidence comparing the effectiveness of these treatment modalities remains limited. This randomized controlled clinical trial aims to compare the effectiveness of Antivet treatment and Opalustre enamel microabrasion in improving the esthetic appearance of mild enamel fluorosis/discolored enamel affecting anterior teeth. Eligible participants with mild enamel fluorosis will be randomly allocated to receive either Antivet treatment or Opalustre enamel microabrasion in a 1:1 ratio. Tooth color will be objectively assessed before and after treatment using a spectrophotometer based on the CIELAB color system (L\*, a\*, and b\* coordinates), and the overall color difference (ΔE) will be calculated. The primary outcome is the change in tooth color following treatment, while secondary outcomes include changes in individual CIELAB color coordinates. The findings of this study are expected to provide evidence regarding the comparative effectiveness of these minimally invasive treatment modalities for the esthetic management of mild enamel fluorosis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 7, 2026
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 18, 2026
Actual (reported)June 15, 2026
Actual (reported)July 7, 2026
Actual (reported)July 9, 2026
Actual (reported)July 16, 2026
Actual (reported)The mean change in color
The primary outcome measure was the change in tooth color following treatment, objectively assessed using a spectrophotometer based on the Commission Internationale de l'Éclairage (CIELAB) color system. Color coordinates (L\*, a\*, and b\*) were recorded at the base line and then after the intervention was applied in the same visit and the overall color difference (ΔE) was calculated to quantify treatment-induced color improvement.
Baseline (before treatment) and immediately after completion of the intervention (same visit Day 1).
Microabrasion
Enamel Micro abrasion
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
October University for Modern Sciences and Arts
Giza, Sixth of October, 12566, Egypt
10.21608/edj.2023.217606.2603
Diab DFS, Elhaddad EEH. Comparative effect of Antivet(R), Oplasture(R), and a prototype paste on color change and microhardness of simulated stained enamel: an in vitro study. BDJ Open. 2025 Dec 30;11(1):100. doi: 10.1038/s41405-025-00393-x.
59 participants (actual enrollment reported by the registry).
Contact the study team to confirm eligibility.
First Submitted
July 9, 2026
First Posted
July 16, 2026
Study Start
May 18, 2026
Actual (reported)Primary Completion
June 15, 2026
Actual (reported)Study Completion
July 7, 2026
Actual (reported)Last Updated
July 16, 2026
Record last verified: 2026-05
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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