Evaluation of AI-Mouse Use in Patients With Hand and Wrist Conditions

NCT07707089 | Not Yet Recruiting

• 1 other identifier: 1220/02042026
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

People with hand and wrist conditions, such as carpal tunnel syndrome or hand injuries, often experience pain and discomfort when using a computer mouse. This study will evaluate a new artificial intelligence (AI)-assisted computer input system ("AI-mouse") designed to reduce the amount of hand movement needed during computer tasks. Participants will complete short computer-based tasks using both a conventional mouse and the AI-assisted system while researchers measure task performance, muscle activity using surface electromyography (EMG), and participants' ratings of pain, physical strain, and usability. The study aims to determine whether the AI-assisted system can reduce physical effort and muscle load while maintaining effective computer interaction. Findings may help improve accessible computer technologies and support the development of ergonomic tools for people with hand and wrist impairments.

Conditions

Carpal Tunnel Syndrome (CTS); Wounds and Injuries, Hands; Wounds and Injuries, Wrists; Hand Injuries; Wrist Injuries

Outcome Measures

Primary Outcomes (2)

• APDF90 surface electromyography (sEMG) amplitude

  90th percentile amplitude probability distribution function (APDF90) of the processed sEMG envelope recorded from selected upper-limb muscles during standardized computer tasks.

  Baseline (during each intervention condition on Day 1)

• Muscular rest time

  Percentage of task duration during which the processed sEMG envelope remained below the predefined muscular-rest threshold of 2 µV.

  Baseline (during each intervention condition on Day 1)

Secondary Outcomes (5)

• Integrated squared dynamic acceleration

  Baseline (during each intervention condition on Day 1)

• 90th percentile dynamic acceleration

  Baseline (during each intervention condition on Day 1)

• Task completion time

  Baseline (during each intervention condition on Day 1)

• Error rate

  Baseline (during each intervention condition on Day 1)

• Self-reported pain

  Immediately after each intervention condition on Day 1

Study Arms (2)

Conventional Mouse

ACTIVE COMPARATOR

Participants perform standardized computer pointing tasks using a conventional computer mouse. Performance (task completion time, error rate, throughput), surface electromyography (EMG) of upper-limb muscles, and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion.

Device: Conventional Computer Mouse

AI-Mouse (Preview-Accept-Discard [PAD] System)

EXPERIMENTAL

Participants perform the same standardized computer tasks using the AI-Mouse, a predictive human-computer interaction system based on the Preview-Accept-Discard (PAD) paradigm. The system generates AI-assisted action suggestions that can be accepted or discarded using minimal keyboard input, reducing cursor movement. Performance, surface electromyography (EMG), and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion.

Device: AI-Assisted Computer Input System

Interventions

AI-Assisted Computer Input System DEVICE

A non-invasive computer input system that uses artificial intelligence to predict the user's intended on-screen action. Instead of relying primarily on continuous cursor movement and mouse clicking, the system presents predicted actions that participants can preview, accept, or discard using minimal keyboard input. The intervention is designed to reduce repetitive hand movements during computer interaction while preserving user control. Participants complete standardized computer tasks using the system during a single study session lasting less than four minutes.

AI-Mouse (Preview-Accept-Discard [PAD] System)

Conventional Computer Mouse DEVICE

A standard computer mouse used for conventional point-and-click interaction. Participants complete the same standardized computer tasks as in the experimental condition, allowing direct comparison of task performance, upper-limb muscle activity measured by surface electromyography (EMG), and participant-reported pain, physical strain, and usability.

Conventional Mouse

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-65 years
• Diagnosis of a hand or wrist condition, including carpal tunnel syndrome or hand/wrist injury.
• Receiving care at the Hand Surgery Department of the National Scientific Center of Traumatology and Orthopedics.
• Medically stable and assessed by a study physician as able to safely perform light computer-based hand movements.
• Able to understand the study procedures and provide written informed consent.
• Normal or corrected-to-normal vision sufficient to complete computer-based tasks.

You may not qualify if:

• Severe pain or acute symptoms that may be aggravated by computer task performance.
• Postoperative restrictions limiting hand or wrist movement.
• Severe motor impairment preventing completion of the study tasks.
• Cognitive or neurological disorders that interfere with understanding study procedures or task performance.
• Uncorrected visual impairment that interferes with computer use.
• Any medical condition that, in the opinion of the study physician, would make participation unsafe.

Sponsors & Collaborators

• Nazarbayev University: lead

MeSH Terms

Conditions

Carpal Tunnel Syndrome; Wounds and Injuries; Hand Injuries; Wrist Injuries

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Arm Injuries

Central Study Contacts

Jose Berengueres, PhD

CONTACT

+7 778 358 18 26; jose.berengueres@nu.edu.kz

Dina Kalinina, MD

CONTACT

+77756238719; dina.kalinina@nu.edu.kz

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 16, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: July 16, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share