NCT07706920

Brief Summary

The goal of this study is to test an artificial intelligence (AI) tool called SAGE. SAGE helps primary care doctors with questions that often need a specialist. Primary care doctors are the doctors people usually see first. SAGE reviews a case and suggests what a specialist might advise. The main questions it aims to answer are:

  • Do doctors make sound, timely care decisions when they use SAGE?
  • Do those decisions match what a specialist would advise? Researchers will compare the decisions doctors make with and without SAGE. Doctors in the study will:
  • Review made-up patient cases (these are not real patients)
  • Make a decision for each case, their usual way and with SAGE

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for not_applicable

Timeline
1mo left

Started Jul 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress51%
Jul 2026Sep 2026

Study Start

First participant enrolled

July 1, 2026

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

July 10, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 16, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

July 16, 2026

Status Verified

July 1, 2026

Enrollment Period

2 months

First QC Date

July 10, 2026

Last Update Submit

July 10, 2026

Conditions

Decision Support Systems, ClinicalReferral and Consultation

Keywords

clinical decision supportelectronic consultationprimary careartificial intelligence

Outcome Measures

Primary Outcomes (2)

  • Clinical actionability of the clinician's decision

    For each case, independent reviewers judge whether the physician's decision is clinically actionable, meaning the physician can act on it now rather than wait for a specialist. The outcome is the proportion of cases judged actionable, measured separately for decisions made with SAGE and for decisions made the standard way.

    Post-session independent review, through study completion (up to approximately 2 months)

  • Concordance of the clinician's decision with the specialist reference answer

    Agreement between the physician's management decision and a specialist reference answer, rated by independent reviewers, with inter-rater agreement summarized. Assessed for decisions made with SAGE and for decisions made the standard way.

    Post-session independent review, through study completion (up to approximately 2 months)

Secondary Outcomes (3)

  • System usability (System Usability Scale, SUS)

    End of study session (Day 1, approximately 60 minutes)

  • Order acceptance in the SAGE condition

    During study session (Day 1)

  • Time to complete case review

    During study session (Day 1)

Study Arms (1)

Primary care physicians

EXPERIMENTAL

Primary care physicians make management decisions on synthetic patient cases. Each physician reviews four cases in random order: two with SAGE (AI clinical decision support) and two using a standard eConsult approach.

Other: SAGE (AI clinical decision support)Other: Standard eConsult

Interventions

SAGE (AI clinical decision support)OTHER

SAGE is an artificial intelligence (AI) based clinical decision support tool. It generates specialty-informed recommendations for a primary care consultation question. Physicians review the SAGE output while making a management decision for the synthetic case.

Primary care physicians
Standard eConsultOTHER

A standard electronic consultation (eConsult) format, without SAGE. Physicians review this information while making a management decision for the synthetic case.

Primary care physicians

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Physician practicing in primary care internal medicine and/or family medicine
  • Attending physician, or resident physician at postgraduate year 2 (PGY-2) or higher
  • Stanford-affiliated (faculty, staff, or trainee)
  • Able to complete a single, approximately 60-minute remote (Zoom) session conducted in English

You may not qualify if:

  • Not currently practicing in primary care internal medicine or family medicine
  • Member of the study team or otherwise involved in the development of SAGE
  • Unable to complete the remote study session

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Stanford University

Stanford, California, 94305, United States

Location

Study Officials

  • Jonathan Chen, MD, PhD

    Stanford University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Medicine

Study Record Dates

First Submitted

July 10, 2026

First Posted

July 16, 2026

Study Start

July 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

July 16, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

US(1)