The Value of Bowel Sounds in Evaluating Postoperative Intestinal Function Recovery in Colorectal Cancer Patients

NCT07705139 | Recruiting DMC

• 1 other identifier: ZNH-2025-BA-02
• Study Type: observational
• Target: 172
• Locations: 1 country
• Sites: 1

Brief Summary

This study enrolls patients scheduled to undergo curative surgery for colorectal cancer. Bowel sounds will be assessed preoperatively and postoperatively. By comparing intraoperative variables, the incidence of perioperative complications, reoperation rates, and postoperative outcomes-including time to first flatus, resumption of oral intake, and occurrence of intestinal obstruction-this study aims to investigate the association between perioperative bowel sounds and postoperative recovery, and provide evidence-based support for the clinical application of bowel sound monitoring. Supplementary Definitions

Conditions

Bowel Sounds; Colorectal Cancer; Intestinal Obstruction; Postoperative Ileus; Colorectal Surgery

Keywords

bowel sounds; Colorectal Cancer; Intestinal Obstruction; Postoperative Ileus; Colorectal Surgery

Outcome Measures

Primary Outcomes (1)

• Occurrence of postoperative ileus ( POI) after surgery.

  From surgery through postoperative day 30

Secondary Outcomes (6)

• Postoperative Complications within 30 Days

  From surgery through postoperative day 30

• Length of postoperative hospital stay

  From surgery through postoperative day 30

• Time to first flatus

  From surgery through postoperative day 30

• Time to first defecation

  From surgery through postoperative day 30

• Total hospitalization cost (before reimbursement)

  From surgery through postoperative day 30

Study Arms (2)

normal group

No intestinal obstruction occurred during the perioperative period.

Procedure: colorectal surgery

POI group

Intestinal obstruction occurred during the perioperative period.

Procedure: colorectal surgery

Interventions

colorectal surgery PROCEDURE

Based on the preoperative multidisciplinary team (MDT) discussion, the appropriate surgical procedure was selected, including right hemicolectomy, left hemicolectomy, or radical resection for rectal cancer, as clinically indicated.

POI group; normal group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study enrolls patients scheduled to undergo curative surgery for colorectal cancer.

You may qualify if:

• Aged 18-80 years.
• Histopathologically confirmed colorectal adenocarcinoma according to the WHO 2022 classification.
• No restriction on prior neoadjuvant or other antitumor therapies, including chemotherapy, radiotherapy, targeted therapy, or immunotherapy.
• Able to understand the study requirements and voluntarily provide written informed consent (patient and/or legally authorized representative).
• Able to communicate effectively with the investigators and willing to comply with all study procedures, including postoperative management and follow-up.

You may not qualify if:

• Significant organ dysfunction indicating inability to tolerate surgery or an unacceptably high perioperative risk, including:
• Severe cardiac dysfunction (NYHA Class III or IV).
• Severe hepatic dysfunction (MELD score \>12).
• Severe renal dysfunction (eGFR \<30 mL/min/1.73 m² \[CKD stage 4-5\] or end-stage renal disease requiring dialysis).
• Severe pulmonary dysfunction (resting PaO₂ \<60 mmHg on room air or respiratory failure requiring long-term oxygen therapy or mechanical ventilation).
• Participation in another clinical study within 4 weeks before enrollment or concurrent participation in another interventional clinical study.
• Emergency surgery required because of intestinal obstruction, perforation, or other acute abdominal conditions.
• Severe psychiatric disorders that would interfere with compliance with perioperative management or follow-up.
• Pregnant or breastfeeding women.
• Any other clinical or laboratory abnormality that, in the opinion of the investigator, would make the participant unsuitable for the study.

Sponsors & Collaborators

• Zhongnan Hospital: lead
• Wuhan University: collaborator

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

RECRUITING

MeSH Terms

Conditions

Colorectal Neoplasms; Intestinal Obstruction

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Congqing Jiang, professor

  Shanghai Zhongshan Hospital

  STUDY CHAIR

Central Study Contacts

siyuan yin, master

CONTACT

+86 18771708286; 2023283030136@whu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 3, 2026
• First Posted: July 15, 2026
• Study Start: February 1, 2026
• Primary Completion: May 15, 2026
• Study Completion: July 28, 2026
• Last Updated: July 15, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

CN (1)