Functional and Physiological Responses to Multicomponent Exercise in Older Adults

NCT07702227 | Active Not Recruiting

• 1 other identifier: 2026-YONP-0121
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine functional and physiological responses to a 12-week multicomponent exercise program in community-dwelling older adults. Adults aged 60 to 81 years will be randomly assigned to either a multicomponent exercise group or a control group. The supervised exercise program will be performed twice weekly for 12 weeks and will include aerobic walking, resistance exercises, balance and agility training, flexibility exercises, and cool-down activities. Functional performance will be assessed using the six-minute walk test, the 30-second chair stand test, and the 8-Foot Up and Go test at baseline and after 12 weeks. Resting cardiac autonomic function will be assessed using heart rate variability. In addition, an exploratory responder-non-responder analysis will be conducted to examine whether baseline heart rate variability is associated with individual functional adaptations following the exercise program. This study may help identify physiological markers related to functional responsiveness to exercise in older adults.

Conditions

Older Adults (60 - 85 Years Old); Aging; Functional Capacity; Exercise Response; Heart Rate Variability (HRV)

Keywords

heart rate variability; cardiac autonomic function; multicomponent exercise; six-minute walk test; responder non-responder

Outcome Measures

Primary Outcomes (1)

• Change in six-minute walk distance

  Functional walking capacity will be assessed using the six-minute walk test. The total distance walked in six minutes will be recorded in meters at baseline and after the 12-week intervention.

  Baseline and 12 weeks

Secondary Outcomes (2)

• Change in 30-second chair stand test performance

  Baseline and after 12 weeks

• Change in 8-foot Up-and-Go test performance

  baseline and after 12 weeks

Other Outcomes (1)

• Change in resting heart rate variability parameters

  Baseline to 12 weeks

Study Arms (2)

multicomponent Exercise group

EXPERIMENTAL

Participants are assigned to either a 12-week supervised multicomponent exercise group or a control group. Outcomes are assessed at baseline and after the 12-week intervention period.

Behavioral: Multicomponent Exercise Program

Control Group

NO INTERVENTION

Participants in the control group will maintain their usual daily activities during the 12-week study period and will not receive the supervised multicomponent exercise program.

Interventions

Multicomponent Exercise Program BEHAVIORAL

Participants in the exercise group will complete a supervised multicomponent exercise program twice weekly for 12 weeks. Each session will last approximately 45 to 50 minutes and include warm-up, aerobic interval walking, resistance exercises, balance and agility training, flexibility exercises, and cool-down activities. Exercise intensity will be monitored using the Borg Rating of Perceived Exertion scale and exercise difficulty will be progressively increased by increasing repetitions, walking duration, walking pace, and task complexity.

multicomponent Exercise group

Eligibility Criteria

• Age: 60 Years - 81 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• being 60 years of age or older,
• being able to walk independently,
• not having any serious cardiovascular, neurological, or musculoskeletal disease that would prevent exercise.
• do not use medications that may affect autonomic nervous system function

You may not qualify if:

• diagnosed cardiac arrhythmia,
• uncontrolled hypertension,
• use of medications that may affect autonomic nervous system function,
• inability to perform functional performance tests.

Sponsors & Collaborators

• Çanakkale Onsekiz Mart University: lead

Study Sites (1)

Canakkale Onsekiz Mart University

Çanakkale, 17100, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Participants are assigned to either a 12-week supervised multicomponent exercise group or a control group. Outcomes are assessed at baseline and after the 12-week intervention period.

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 14, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): September 21, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: July 14, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)