Placental Progesterone Membrane Receptors in Fetal Growth Restriction

NCT07701837 | Recruiting

• 1 other identifier: OMUK2025/309
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, between pregnancies complicated by intrauterine growth restriction (IUGR) and uncomplicated healthy pregnancies. Placental tissue samples obtained at delivery will be analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). The study also aims to investigate the association between receptor expression levels and perinatal outcomes in order to better understand the role of progesterone membrane receptors in the pathophysiology of IUGR.

Conditions

Fetal Growth Restriction; Placenta; Progesterone Membrane Receptor; PGRMC1; PGRMC2; Placental Dysfunction; Pregnancy

Outcome Measures

Primary Outcomes (1)

• Placental PGRMC1,PGRMC2 and PAQR mRNA expression levels

  Relative placental mRNA expression levels of PGRMC1, PGRMC2 and PAQR family receptors measured by quantitative real-time polymerase chain reaction (qRT-PCR) in placental tissue collected immediately after delivery.

  At delivery

Other Outcomes (1)

• association between placental progesterone membrane receptor expression and neonatal outcomes

  at delivery

Study Arms (2)

Fetal Growth Restriction Group

Pregnant women diagnosed with fetal growth restriction who will undergo placental tissue collection at delivery for molecularanalysis.

Healthy Control Group

Healthy pregnant women with appropriate fetal growth who will undergo placental tissue collection at delivery for molecular analysis.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women aged 18-45 years delivering at Samsun Training and Research Hospital will be enrolled. The study population will consist of women with singleton pregnancies complicated by fetal growth restriction (FGR) and healthy pregnant women with appropriate fetal growth serving as the control group. Placental tissue samples will be collected immediately after delivery for molecular analysis.

You may qualify if:

• Singleton pregnancy Maternal age 18-45 years Diagnosis of IUGR according to institutional criteria

You may not qualify if:

• Multiple pregnancy Major fetal structural anomaly Chromosomal abnormality Congenital infection Maternal chronic systemic disease Autoimmune disease Chronic hypertension Pregestational diabetes mellitus Placental abruption Intrauterine fetal demise

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun University Faculty of Medicine Samsun Training and Research Hospital

Samsun, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Fetal Growth Retardation

Condition Hierarchy (Ancestors)

Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Canan Soyer Çalışkan, MD, Associate Professor

  Samsun University, Samsun Education and Research Hospital, Samsun, Turkey

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Canan SOYER ÇALIŞKAN, MD, Associate Professor

CONTACT

+ 90 532 203 55 38; canan.caliskan@samsun.edu.tr

Canan SOYER ÇALIŞKAN, MD, Associate Professor

CONTACT

90 362 311 15 40; canan.caliskan@samsun.edu.tr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 14, 2026
• Study Start: November 1, 2025
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: July 14, 2026

Record last verified: 2026-07

Locations

TU (1)