Ionized Calcium Changes for Predicting Postoperative Hypocalcemia After Total Thyroidectomy

NCT07701824 | Completed DMC

• 1 other identifier: KAEK-11/12.03.2025.87
• Study Type: observational
• Target: 327
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate whether changes in ionized calcium levels measured by blood gas analysis during the preoperative, intraoperative, and postoperative periods can predict postoperative hypocalcemia in patients undergoing total thyroidectomy. Ionized calcium values obtained at predefined perioperative time points will be compared with postoperative biochemical and clinical hypocalcemia outcomes.

Conditions

Postoperative Hypocalcemia; Postoperative Hypoparathyroidism; Total Thyroidectomy

Keywords

ionized calcium; blood gas analysis; total thyroidectomy; postoperative hypocalcemia; postoperative hypoparathyroidism; calcium monitoring

Outcome Measures

Primary Outcomes (2)

• ionized calcium

  Ionized calcium levels will be measured by blood gas analysis at predefined preoperative and postoperative time points in patients undergoing total thyroidectomy.

  Preoperative baseline; postoperative 10 minutes; postoperative 6 hours

• parathormone levels

  Serum parathyroid hormone levels will be measured in patients undergoing total thyroidectomy to evaluate the association between postoperative parathyroid hormone changes and postoperative hypocalcemia.

  Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months

Study Arms (1)

total thyroidectomy patients

Diagnostic Test: Calcium

Interventions

Calcium DIAGNOSTIC_TEST

Ionized calcium levels will be measured by blood gas analysis at predefined preoperative, intraoperative, and postoperative time points in patients undergoing total thyroidectomy.

total thyroidectomy patients

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to Başakşehir Çam and Sakura City Hospital who are scheduled to undergo total thyroidectomy.

You may qualify if:

• Patients aged 18 to 75 years
• Present to the General Surgery Clinic of Başakşehir Çam and Sakura City Hospital
• Diagnosis of thyroid disorders according to ICD code E07
• Scheduled to undergo total thyroidectomy due to toxic multinodular goiter, multinodular goiter, or papillary carcinoma
• Provide informed consent to participate in the study.

You may not qualify if:

• Patients with preoperative parathyroid disorders associated hypocalcemia or hypercalcemia.
• Patients with a history of previous thyroidectomy
• Patients with a history of previous parathyroidectomy
• Patients with a history of previous neck surgery.
• Patients with chronic kidney disease.
• Patients with a history of non-thyroid malignancy.

Sponsors & Collaborators

• Emrecan Deniz: lead

Study Sites (1)

Basaksehir Cam and Sakura City Hospital

Başakşehir, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Calcium Signaling

Intervention Hierarchy (Ancestors)

Second Messenger Systems; Signal Transduction; Biochemical Phenomena; Chemical Phenomena; Ion Transport; Biological Transport; Metabolism; Cell Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident, Depertment of General Surgery

Study Record Dates

• First Submitted: June 26, 2026
• First Posted: July 14, 2026
• Study Start: June 12, 2025
• Primary Completion: April 25, 2026
• Study Completion: July 5, 2026
• Last Updated: July 14, 2026

Record last verified: 2025-07

Locations

TU (1)