A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.

NCT07695545 | Recruiting

• 1 other identifier: BLITTI 2026-1
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality. Their pathophysiology is based on complex mechanisms involving inflammatory and metabolic processes, as well as alterations in mitochondrial function. The presence of a bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) significantly influences the progression and severity of aneurysms. Bicuspid aortic valve (BAV) patients often develop aortic aneurysms earlier, as early as age 40-50, whereas tricuspid aortic valve (TAV) patients generally present with a degenerative condition that appears later (after age 50). The objective of this study is to compare the inflammatory, metabolic, and transcriptomic signatures of myeloid cells and total aortic tissue between BAV and TAV patients. These analyses will help identify specific molecular mechanisms, potential biomarkers, and therapeutic targets. To ensure pathophysiological homogeneity, patients with aneurysms of genetic origin (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) will be excluded.

Conditions

Ascending Aortic Aneurysm

Outcome Measures

Primary Outcomes (1)

• Inflammatory, metabolic, and transcriptomic markers of myeloid cells and aortic tissue

  At the time of surgery

Study Arms (2)

Patient with an ascending aortic aneurysm and a bicuspid aortic valve (BAV)

Patient with an ascending aortic aneurysm and a bicuspid aortic valve (BAV)

Procedure: Additional blood samples; Procedure: Collection of discarded ascending aortic tissue

Patient with an ascending aortic aneurysm and a tricuspid aortic valve (TAV)

Patient with an ascending aortic aneurysm and a tricuspid aortic valve (TAV)

Procedure: Additional blood samples; Procedure: Collection of discarded ascending aortic tissue

Interventions

Additional blood samples PROCEDURE

Additional blood sample are collected at the time of routine clinical blood sampling for recherche analyses.

Patient with an ascending aortic aneurysm and a bicuspid aortic valve (BAV); Patient with an ascending aortic aneurysm and a tricuspid aortic valve (TAV)

Collection of discarded ascending aortic tissue PROCEDURE

The aneurysmal portion of the ascending aorta (surgical specimen), which would otherwise be discarded, is collected for research purposes. No other tissue is collected, and the research protocol does not alter the surgical procedure.

Patient with an ascending aortic aneurysm and a bicuspid aortic valve (BAV); Patient with an ascending aortic aneurysm and a tricuspid aortic valve (TAV)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with ascending aortic aneurysms

You may qualify if:

• Individuals who have given their consent
• Patients with an ascending aortic aneurysm for which surgical replacement is indicated
• Age \> 18 years
• Scheduled surgery
• Preoperative ultrasound confirmation of the heart valve architecture (bicuspid or tricuspid valve)

You may not qualify if:

• A person subject to a legal protective measure (guardianship, conservatorship)
• A person subject to a judicial safeguard measure - A pregnant woman, a woman in labor, or a breastfeeding woman
• Adults who are legally incapacitated or unable to give consent
• Emergency surgical procedures
• Patients with uncontrolled inflammatory or autoimmune conditions
• Patients with a history of recent acute infection (within the last 3 months or still undergoing treatment)
• Patients with a condition requiring immunosuppressants - Patients with a confirmed or suspected genetic aneurysm (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.)
• Patients with a history of cardiac surgery

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

RECRUITING

MeSH Terms

Conditions

Aneurysm, Ascending Aorta

Condition Hierarchy (Ancestors)

Aortic Aneurysm, Thoracic; Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases

Central Study Contacts

Comlan BLITTI

CONTACT

03.80.29.33.52; comlanmawuko.blitti@chu-dijon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 6, 2026
• First Posted: July 10, 2026
• Study Start: June 28, 2026
• Primary Completion (Estimated): August 1, 2029
• Study Completion (Estimated): August 1, 2029
• Last Updated: July 13, 2026

Record last verified: 2026-07

Locations

FR (1)