Nailfold Capillaroscopic Changes in Psoriasis

NCT07693595 | Recruiting

• 1 other identifier: PSO-NFC-PASI-2026
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity. The study will also explore differences in capillaroscopic findings across different clinical types of psoriasis and skin phototypes (Fitzpatrick classification). The study will include patients diagnosed with psoriasis attending dermatology outpatient clinics. Participants will undergo clinical assessment and nailfold capillaroscopy to detect microvascular changes.

Conditions

Psoriasis

Outcome Measures

Primary Outcomes (1)

• Nailfold capillaroscopic abnormalities in psoriasis patients

  Detection and description of nailfold capillaroscopic (NFC) abnormalities in patients with psoriasis.

  Baseline

Secondary Outcomes (1)

• Variation of nailfold capillaroscopic findings among different clinical types of psoriasis and correlation with disease severity (PASI score).

  Baseline

Interventions

Nailfold Capillaroscopy OTHER

Participants will undergo nailfold capillaroscopy using a USB digital capillaroscope to assess microvascular changes in psoriatic patients. Clinical assessment including PASI score and evaluation of nail involvement will also be performed.

Also known as: Dermoscopy (if used for nails)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will include patients clinically diagnosed with psoriasis attending the dermatology outpatient clinics at Al-Hussein and Sayed Galal University Hospitals in Cairo, Egypt during the study period.

You may qualify if:

• Patients clinically diagnosed with psoriasis.

You may not qualify if:

• Patients with connective tissue diseases (e.g., systemic sclerosis, SLE)
• Diabetes mellitus or peripheral vascular disease
• Current smokers
• Pregnant or lactating women
• Recent use of vasodilators or beta-blockers
• Manual workers exposed to vibrating tools

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Al-Hussein University Hospital & Sayed Galal University Hospital

Cairo, Cairo Governorate, Egypt

RECRUITING

MeSH Terms

Conditions

Psoriasis

Interventions

Microscopic Angioscopy; Dermoscopy

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Intravital Microscopy; Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Cardiovascular; Investigative Techniques

Central Study Contacts

Ahmed H Nouh, Asst Prof Derm & Venereol

CONTACT

+201062034079; Dr.ahmednouh@azhar.edu.eg

Hadil J Albarrawi

CONTACT

+201096205545; hadeeljamil71@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Dermatology & Venereology

Study Record Dates

• First Submitted: July 4, 2026
• First Posted: July 9, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 31, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)