Does Anesthesia Technique Impact on the Long-term Outcome 5 and 10 Years After the First Intervention in Primary Breast Cancer Surgery? A Follow-up Analysis.

NCT07689253 | Completed

• 1 other identifier: 2025 - 00668
• Study Type: observational
• Target: 161
• Locations: 1 country
• Sites: 1

Brief Summary

Goal of this observational study is to analyze data about cancer recurrence rates 5 and 10 years after primary breast cancer surgery with propofol or sevoflurane anesthesia. Only patients who were enrolled in the primary interventional trial can participate.

Conditions

Follow Up Analysis; Breast Cancer Females; Circulating Tumor Cells.Breast

Keywords

Circulating Tumor Cells; Follow Up Study

Outcome Measures

Primary Outcomes (1)

• Primary co-outcomes are defined as overall survival and disease-free survival.

  A 5- and 10-year follow-up will be performed for all patients participating in the initial study. In this follow-up, we aim to show both groups' cancer recurrence rates and survival curves 5 and 10 years after surgery.

  5 and 10 years after first enrollement

Study Arms (1)

Only Patient who were enrolled into the clinical trial CEC 2016 - 01791.

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Only patients who participated in the clinical trial (CEC 2016 - 01791) can be included into this study.

You may qualify if:

• Only patients who consented and participated in the trial CEC N° 2016 - 01791 can be enrolled.
• GC must be available for patients with follow-up consultations at USZ.
• For patients with follow-up consultations outside of the USZ for those with unknown GC status, and for those who declined the GC, a study-specific written informed consent must be obtained, which will allow the research team to contact the responsible physician

You may not qualify if:

• Declined study-specific informed consent
• Inability to provide study-specific consent

Sponsors & Collaborators

• University Hospital, Zürich: collaborator
• University of Zurich: lead

Study Sites (1)

University Hospital Zurich, Institute of Anesthesiology and Perioperative Medicine

Zurich, Canton of Zurich, 8091, Switzerland

Location

Related Publications (2)

• Enlund M, Berglund A, Enlund A, Lundberg J, Warnberg F, Wang DX, Ekman A, Ahlstrand R, Flisberg P, Hedlund L, Ostlund I, Bergkvist L; CAN-study group. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. EClinicalMedicine. 2023 Jun 9;60:102037. doi: 10.1016/j.eclinm.2023.102037. eCollection 2023 Jun.

  PMID: 37333664 BACKGROUND

• Hovaguimian F, Braun J, Z'graggen BR, Schlapfer M, Dumrese C, Ewald C, Dedes KJ, Fink D, Rolli U, Seeberger M, Tausch C, Papassotiropoulos B, Puhan MA, Beck-Schimmer B. Anesthesia and Circulating Tumor Cells in Primary Breast Cancer Patients: A Randomized Controlled Trial. Anesthesiology. 2020 Sep;133(3):548-558. doi: 10.1097/ALN.0000000000003409.

  PMID: 32568845 BACKGROUND

MeSH Terms

Conditions

Neoplastic Cells, Circulating

Condition Hierarchy (Ancestors)

Neoplasm Metastasis; Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Martin Schläpfer, Prof. Dr. med. M.Sc.

  University of Zurich

  PRINCIPAL INVESTIGATOR

• Beatrice Beck Schimmer, Prof. Dr. med

  University of Zurich

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 16, 2025
• First Posted: July 8, 2026
• Study Start: September 1, 2025
• Primary Completion: January 15, 2026
• Study Completion: April 30, 2026
• Last Updated: July 8, 2026

Record last verified: 2026-06

Locations

CH (1)