Evaluating the Outcome of Surgical Clip Versus Ligatures in Securing Base of Appendix in Laparoscopic Appendicectomy.

NCT07689123 | Completed

• 2 other identifiers: USM/JEPeM/KK/25010103RSCH ID-24-06580-CZW
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the outcome of using surgical clip versus ligature to secure the base of appendix during laparoscopic appendicectomy. The main questions it aims to answer are to compare the post op complications. Compare the length of hospital stay and to compare the impact of cost. Researches will compare the use of surgical clip versus a suture ligature. Participants whom agreed to participate will be randomly assigned into group either using surgical clip or suture ligature to be used during the surgery. Vitis outpatient clinic after 1 month for follow up.

Conditions

Appendicitis (Diagnosis)

Outcome Measures

Primary Outcomes (1)

• To compare the post operative complications

  Post operative complications monitored with the use of Clavein Dindo classification

  up to 1 month post op

Secondary Outcomes (2)

• Length of stay

  1 month

• Cost

  1 month

Study Arms (2)

Surgical clip

EXPERIMENTAL

single polymeric clip (XXL Click'aV Plus, Grena) will be used to secure the base of the appendix

Device: single polymeric clip (XXL Click'aV Plus, Grena)

Suture ligature

ACTIVE COMPARATOR

2 Suture ligature Laprotie (Ecosorb 0 , Vigilenz) will be used to secure the base of appendix

Device: suture ligature

Interventions

single polymeric clip (XXL Click'aV Plus, Grena) DEVICE

single polymeric clip (XXL Click'aV Plus, Grena)

Surgical clip

suture ligature DEVICE

2 suture ligatures will be used to secure base of appendic

Suture ligature

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>18 years old
• Both genders
• Planned for laparoscopic appendicectomy

You may not qualify if:

• Patient not consented
• Appendix perforated at base or unhealthy appendix base
• Conversion to open appendicectomy
• Diagnosed with other pathology intra-operatively
• Pregnant patients

Sponsors & Collaborators

• Universiti Sains Malaysia: lead

Study Sites (1)

Hospital Seberang Jaya

Seberang Jaya, Pulau Pinang, 13700, Malaysia

Location

Related Publications (13)

• Colak E, Kement M, Ozlem N, Mutlu T, Yildirim K, Gurer A, Aktimur R. A comparison of nonabsorbable polymeric clips and endoloop ligatures for the closure of the appendicular stump in laparoscopic appendectomy: a prospective, randomized study. Surg Laparosc Endosc Percutan Tech. 2013 Jun;23(3):255-8. doi: 10.1097/SLE.0b013e31828b8382.

  PMID: 23751988 BACKGROUND

• Delibegovic S, Mehmedovic Z. The influence of the different forms of appendix base closure on patient outcome in laparoscopic appendectomy: a randomized trial. Surg Endosc. 2018 May;32(5):2295-2299. doi: 10.1007/s00464-017-5924-z. Epub 2017 Nov 2.

  PMID: 29098432 BACKGROUND

• Tan TM, Okada M. The efficiency of absorbable clips in minimally invasive surgery. Surg Today. 1999;29(8):828-31. doi: 10.1007/BF02482340.

  PMID: 10483770 BACKGROUND

• Delibegovic S, Iljazovic E, Katica M, Koluh A. Tissue reaction to absorbable endoloop, nonabsorbable titanium staples, and polymer Hem-o-lok clip after laparoscopic appendectomy. JSLS. 2011 Jan-Mar;15(1):70-6. doi: 10.4293/108680811X13022985131336.

  PMID: 21902947 BACKGROUND

• Delibegovic S, Matovic E. Hem-o-lok plastic clips in securing of the base of the appendix during laparoscopic appendectomy. Surg Endosc. 2009 Dec;23(12):2851-4. doi: 10.1007/s00464-009-0493-4. Epub 2009 May 14.

  PMID: 19440790 BACKGROUND

• Delibegovic S. The use of a single Hem-o-lok clip in securing the base of the appendix during laparoscopic appendectomy. J Laparoendosc Adv Surg Tech A. 2012 Jan-Feb;22(1):85-7. doi: 10.1089/lap.2011.0348. Epub 2011 Dec 6.

  PMID: 22145605 BACKGROUND

• Arcovedo R, Barrera H, Reyes HS. Securing the appendiceal stump with the Gea extracorporeal sliding knot during laparoscopic appendectomy is safe and economical. Surg Endosc. 2007 Oct;21(10):1764-7. doi: 10.1007/s00464-007-9239-3. Epub 2007 Mar 13.

  PMID: 17353987 BACKGROUND

• Kazemier G, in't Hof KH, Saad S, Bonjer HJ, Sauerland S. Securing the appendiceal stump in laparoscopic appendectomy: evidence for routine stapling? Surg Endosc. 2006 Sep;20(9):1473-6. doi: 10.1007/s00464-005-0525-7. Epub 2006 Jul 3.

  PMID: 16823654 BACKGROUND

• Hanssen A, Plotnikov S, Dubois R. Laparoscopic appendectomy using a polymeric clip to close the appendicular stump. JSLS. 2007 Jan-Mar;11(1):59-62.

  PMID: 17651557 BACKGROUND

• Hue CS, Kim JS, Kim KH, Nam SH, Kim KW. The usefulness and safety of Hem-o-lok clips for the closure of appendicular stump during laparoscopic appendectomy. J Korean Surg Soc. 2013 Jan;84(1):27-32. doi: 10.4174/jkss.2013.84.1.27. Epub 2012 Dec 26.

  PMID: 23323232 BACKGROUND

• Hardin DM Jr. Acute appendicitis: review and update. Am Fam Physician. 1999 Nov 1;60(7):2027-34.

  PMID: 10569505 BACKGROUND

• Partecke LI, Kessler W, von Bernstorff W, Diedrich S, Heidecke CD, Patrzyk M. Laparoscopic appendectomy using a single polymeric clip to close the appendicular stump. Langenbecks Arch Surg. 2010 Nov;395(8):1077-82. doi: 10.1007/s00423-010-0671-9. Epub 2010 Jun 26.

  PMID: 20577759 BACKGROUND

• Poon SHT, Law SY, Lai ATY. Clips closure versus endoloop ligation in laparoscopic appendectomy: a systematic review and meta-analysis of comparative studies. Ann Med Surg (Lond). 2023 Sep 6;85(10):5011-5021. doi: 10.1097/MS9.0000000000001260. eCollection 2023 Oct.

  PMID: 37811063 BACKGROUND

MeSH Terms

Conditions

Appendicitis; Disease

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• THEOANN LYCIA DANIEL

  Universiti Sains Malaysia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: March 20, 2026
• First Posted: July 8, 2026
• Study Start: July 1, 2025
• Primary Completion: February 10, 2026
• Study Completion: February 27, 2026
• Last Updated: July 8, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

MY (1)