The Effect of SPU on Hormonal and Cardiometabolic Factors

NCT07688824 | Completed DMC

• 1 other identifier: JUST121212
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.

Conditions

Hypothyroidism; Hypertension; Healthy Adult; Hyperthyroidism; Diabete Mellitus

Keywords

Hypothyroid; Soleus Pushup; Hormones

Outcome Measures

Primary Outcomes (28)

• Total cholesterol

  Total cholesterol will be measured in blood and reported in mg/dL.

  3 hours

• Triglycerides

  Triglycerides will be measured in blood and reported in mg/dL.

  3 hours

• HDL-C

  High-density lipoprotein cholesterol will be measured in blood and reported in mg/dL.

  3 hours

• LDL-C

  Low-density lipoprotein cholesterol will be calculated using the lipid profile and reported in mg/dL.

  3 hours

• VLDL-C

  Very-low-density lipoprotein cholesterol will be calculated from triglycerides and reported in mg/dL.

  3 hours

• Non-HDL cholesterol

  Non-HDL cholesterol will be calculated as total cholesterol minus HDL-C and reported in mg/dL.

  3 hours

• Apolipoprotein A-I

  Apolipoprotein A-I will be measured in blood and reported in mg/dL.

  3 hours

• Apolipoprotein B

  Apolipoprotein B will be measured in blood and reported in mg/dL.

  3 hours

• Lipoprotein(a)

  Lipoprotein(a) will be measured in blood and reported in mg/dL or nmol/L, depending on the laboratory assay.

  3 hours

• Fasting blood glucose

  Fasting blood glucose will be measured in blood and reported in mg/dL.

  3 hours

• Random blood glucose

  Random blood glucose will be measured in blood and reported in mg/dL.

  3 hours

• HbA1c

  Glycated hemoglobin will be measured in blood and reported as a percentage.

  3 hours

• Insulin

  Insulin will be measured in blood and reported in µIU/mL or mIU/L, depending on the laboratory assay.

  3 hours

• Glucagon

  Glucagon will be measured in blood and reported in pg/mL.

  3 hours

• Catecholamines

  Catecholamines will be measured in blood and reported in pg/mL.

  3 hours

• Thyroid-stimulating hormone

  Thyroid-stimulating hormone will be measured in blood and reported in mIU/L or µIU/mL, depending on the laboratory assay.

  3 hours

• Triiodothyronine

  Triiodothyronine will be measured in blood and reported in ng/dL.

  3 hours

• Thyroxine

  Thyroxine will be measured in blood and reported in µg/dL.

  3 hours

• Brain-derived neurotrophic factor

  Brain-derived neurotrophic factor will be measured in blood and reported in pg/mL or ng/mL, depending on the laboratory assay.

  3 hours

• Leptin

  Leptin will be measured in blood and reported in ng/mL.

  3 hours

• Adiponectin

  Adiponectin will be measured in blood and reported in µg/mL.

  3 hours

• Glucagon-like peptide

  Glucagon-like peptide will be measured in blood and reported in pmol/L or pg/mL, depending on the laboratory assay.

  3 hours

• Heart rate

  Heart rate will be measured using the standard auscultatory method and reported in beats per minute.

  3 hours

• Systolic blood pressure

  Systolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.

  3 hours

• Diastolic blood pressure

  Diastolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.

  3 hours

• Pulse pressure

  Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure and reported in mmHg.

  3 hours

• Rate-pressure product

  Rate-pressure product will be calculated as heart rate multiplied by systolic blood pressure and reported in bpm × mmHg.

  3 hours

• Mean arterial pressure

  Mean arterial pressure will be calculated as diastolic blood pressure plus one-third of pulse pressure and reported in mmHg.

  3 hours

Study Arms (2)

Hypothyroid patients

EXPERIMENTAL

Hypothyroid patients

Behavioral: Soleus pushup exercise

Health controls

EXPERIMENTAL

Health controls

Behavioral: Soleus pushup exercise

Interventions

Soleus pushup exercise BEHAVIORAL

The participants are given the soleus push-up exercise

Health controls; Hypothyroid patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals aged 18-80,
• Patients diagnosed with hypothyroidism
• Patients diagnosed with hyperthyroidism
• Patients diagnosed with hypertension
• Patients diagnosed with diabetes mellitus
• Prediabetics
• Individuals who usually avoid regular physical/muscular activities involving lower limbs
• Age/gender matched apparently healthy individuals

You may not qualify if:

• Patients diagnosed with orthopedic diseases
• Patients diagnosed with cardiovascular diseases (other than hypertension)
• Patients diagnosed with renal dysfunction

Sponsors & Collaborators

• King Abdullah University Hospital: lead

Study Sites (1)

Rehabilitation Sciences

Irbid, Irbid Governorate, 22110, Jordan

Location

MeSH Terms

Conditions

Hypothyroidism; Hypertension; Diabetes Mellitus; Hyperthyroidism

Condition Hierarchy (Ancestors)

Thyroid Diseases; Endocrine System Diseases; Vascular Diseases; Cardiovascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The intervention is given to hypothyroid patients and healthy controls.

Study Record Dates

• First Submitted: May 24, 2026
• First Posted: July 7, 2026
• Study Start: March 1, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-06

Locations

JO (1)