Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia

NCT07688057 | Completed

• 2 other identifiers: RTEU-2024-TEAVAP2024-KAEK-25
• Study Type: interventional
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)

Conditions

Ventilation Acquired Pneumonia; Mechanical Ventilation; Oral Care

Keywords

VAP; Oral care; green tea; white tea; clorhexidine

Outcome Measures

Primary Outcomes (1)

• ventilator associated pneumonia devolopment

  Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.

  7 days

Study Arms (3)

chlorhexidine group

EXPERIMENTAL

Participants received oral care using chlorhexidine solution according to the study protocol.

Procedure: Clorhexidine group

green tea group

EXPERIMENTAL

Participants received oral care using green tea according to the study protocol.

Procedure: Green Tea group

white tea group

EXPERIMENTAL

Participants received oral care using white tea according to the study protocol.

Procedure: white tea group

Interventions

Clorhexidine group PROCEDURE

oral care using clorhexidine solution, green tea and white tea

Also known as: clorhexidine

chlorhexidine group

Green Tea group PROCEDURE

Participants received oral care using green tea according to the study protocol.

Also known as: green tea

green tea group

white tea group PROCEDURE

Participants received oral care using white tea according to the study protocol.

white tea group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged over 18 years
• With no known allergies
• Receiving invasive mechanical ventilator support
• With a negative endotracheal aspirate culture on the day of ICU admission
• Within the first 24 hours of mechanical ventilator support
• Patients whose relatives agreed to participate in the study

You may not qualify if:

• Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission,
• Patients undergoing radiotherapy or chemotherapy,
• Patients with contraindications for oral care,
• Patients with a platelet count below 30,000/mm³,
• Patients who cannot be positioned appropriately,
• Patients with agitation severe enough to prevent the procedure from being performed

Sponsors & Collaborators

• Recep Tayyip Erdogan University: lead

Study Sites (1)

Recep Tayyip Erdogan University Research and Training Hospital

Rize, Merkez, 53020, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Tea

Intervention Hierarchy (Ancestors)

Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Intensive care specialist

Model Details: Participants were assigned to one of three parallel intervention groups receiving chlorhexidine, green tea, or white tea oral care throughout the study period.

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 7, 2026
• Study Start: January 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: April 1, 2026
• Last Updated: July 8, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)