AI Chatbot Education for Improving HPV Knowledge Among University Students

NCT07684378 | Completed DMC

• 2 other identifiers: PVF-HPV-AI-2026EKK25-26/15/08
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students. This randomized controlled trial aims to evaluate the effectiveness of an artificial intelligence (AI) chatbot-based educational program in improving HPV knowledge among undergraduate nursing students at Cyprus International University. Participants will be randomly assigned to either an AI chatbot-based personalized education group or a control group receiving standard written educational materials. HPV knowledge will be assessed before and after the intervention using the validated HPV Knowledge Questionnaire. The findings will provide evidence regarding the effectiveness of AI-supported educational strategies for improving HPV-related knowledge among university students

Conditions

HPV Knowledge

Keywords

Papillomavirus Vaccines; Health Education; Educational Technology; AI Chatbot; Health Knowledge

Outcome Measures

Primary Outcomes (1)

• HPV Knowledge Score

  The primary outcome measure assesses changes in participants' knowledge of Human Papillomavirus (HPV) following the educational intervention. HPV knowledge is measured using the validated 29-item HPV Knowledge Questionnaire developed by Waller et al. (2013). The questionnaire evaluates three domains: general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge. Higher total scores indicate greater HPV-related knowledge

  Baseline (before the educational intervention) and 1 month after completion of the educational intervention.

Study Arms (2)

AI Chatbot-Based Education

EXPERIMENTAL

Participants in this group received personalized education about Human Papillomavirus (HPV) through an artificial intelligence (AI) chatbot. The educational content was tailored according to each participant's baseline HPV knowledge and covered HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions

Behavioral: AI Chatbot-Based Education

Standard Written Education

ACTIVE COMPARATOR

Participants in this group received standard written educational materials covering the same HPV-related topics, including HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. No personalized feedback or AI chatbot interaction was provided

Behavioral: Standard Written Education

Interventions

AI Chatbot-Based Education BEHAVIORAL

Participants received personalized education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions. The chatbot provided interactive, personalized educational support throughout the intervention

AI Chatbot-Based Education

Standard Written Education BEHAVIORAL

Participants received standard written educational materials covering HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. The educational materials were identical in content to the intervention group but were provided without personalization or AI chatbot interaction

Standard Written Education

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All students, both female and male, first semester of bachelor's degree, studying in nursing department Enrollment at Cyprus International University
• Willingness to participate and provide written informed consent
• No prior formal education on HPV

You may not qualify if:

• Withdrawal of consent at any stage of the study
• Failure to complete either the pre-test or post-test assessments
• Incomplete participation in the educational intervention

Sponsors & Collaborators

• Near East University, Turkey: lead

Study Sites (1)

Pouran Varvani Farahani

Nicosia, North Cyprus, Cyprus

Location

MeSH Terms

Conditions

Health Education

Condition Hierarchy (Ancestors)

Adherence Interventions; Medication Adherence; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Officials

• Pouran Varvani Farahani, PhD

  PhD in Pediatric Nursing, Department of Nursing, Faculty of Health Science, Cyprus International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: To reduce bias, the statistician responsible for data analysis remained blinded to group allocation. Group assignments were coded as Group A and Group B during statistical analysis.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD in Pediatric Nursing, Department of Nursing, Faculty of Health Science, Cyprus International University

Model Details: Participants were randomly assigned to one of two groups: an AI chatbot-based personalized education group and a control group receiving standard written educational materials. Both interventions were designed to improve knowledge of Human Papillomavirus (HPV), HPV-related diseases, and HPV vaccination. HPV knowledge was assessed before and after the educational intervention using the validated HPV Knowledge Questionnaire to evaluate the effectiveness of the AI chatbot-based educational program.

Study Record Dates

• First Submitted: June 29, 2026
• First Posted: July 6, 2026
• Study Start: March 1, 2026
• Primary Completion: April 20, 2026
• Study Completion: May 30, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CY (1)