EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT

NCT07682246 | Not Yet Recruiting

• 2 other identifiers: APHP260009IDRCB 2026-A00031-50
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions. Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.

Conditions

Thrombocytopenia; Prophylactic Platelet Transfusion; Platelet Transfusion; Endothelial Function

Keywords

ICU; intensive care; Platelet Transfusion; Endothelial Function; endothelial biomarkers; systemic inflammation; oxidative stress; peripheral tissue perfusion

Outcome Measures

Primary Outcomes (1)

• Assessing the effects of platelet transfusion on endothelial function in the microcirculation. Endothelial function will be measured using a Doppler laser coupled with an acetylcholine iontophoresis system applied to the skin.

  The area under the microcirculatory blood flow curve is measured over 10 minutes using a cutaneous laser Doppler sensor coupled with iontophoresis (Périmed, France). The data is analysed using computer software connected to the Doppler device.

  before transfusion, right after transfusion and 1 hour after transfusion

Secondary Outcomes (7)

• Endothelial biomarker levels

  before transfusion and 1 hour after transfusion

• Systemic inflammatory biomarker levels

  before transfusion and 1 hour after transfusion

• Oxidative stress

  before transfusion and 1 hour after transfusion

• Peripheral tissue perfusion

  before transfusion, right after transfusion and 1 hour after transfusion

• Peripheral tissue perfusion

  before transfusion, right after transfusion and 1 hour after transfusion

Study Arms (1)

Transfusion

Patients with thrombocytopenia who are admitted to intensive care for any reason and require prophylactic platelet transfusion.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Any adult admitted to intensive care, regardless of the reason, who has thrombocytopenia and requires prophylactic platelet transfusion

You may qualify if:

• Adult patient ≥ 18 years of age
• Admitted to intensive care
• Requires prophylactic platelet transfusion for thrombocytopenia
• Enrolled in a social security program
• No objection to participating in the study

You may not qualify if:

• Recent platelet or red blood cell transfusion (\< 24 hours)
• Need for urgent red blood cell transfusion due to active bleeding
• Patient under guardianship or conservatorship
• Significant peripheral edema

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Medical Intensive Care Unit, Saint-Antoine Hospital, AP-HP, Paris, France

Paris, 75012, France

Location

MeSH Terms

Conditions

Thrombocytopenia

Condition Hierarchy (Ancestors)

Blood Platelet Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Cytopenia

Study Officials

• Hafid AIT-OUFELLA, Pr

  APHP

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hafid AIT-OUFELLA, Pr

CONTACT

01 49 28 23 15; hafid.aitoufella@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2026
• First Posted: July 2, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: July 2, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)