NCT07678749

Brief Summary

aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at below P25 for not_applicable

Timeline
4mo left

Started Nov 2025

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress69%
Nov 2025Dec 2026

Study Start

First participant enrolled

November 5, 2025

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

June 25, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 1, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 10, 2026

Expected
21 days until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

July 1, 2026

Status Verified

June 1, 2026

Enrollment Period

1 year

First QC Date

June 25, 2026

Last Update Submit

June 25, 2026

Conditions

Closed Sinus LiftApigenin Loaded Scaffold

Outcome Measures

Primary Outcomes (1)

  • 1. Bone height ( Apical Bone Height Gain ): Measured from first implant thread to sinus floor.

    6 months

Study Arms (2)

control

SHAM COMPARATOR

closed sinus lifting using xenograft alone, followed by implant placement.

Procedure: sinus lifting

test group

EXPERIMENTAL

closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.

Procedure: sinus lifting

Interventions

sinus liftingPROCEDURE

closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.

controltest group

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • \. Partially edentulous patients with a maxillary posterior edentulous ridge for more than 4 months after extraction.
  • \. Both males and females. 3. Adults aged between 18-50 years. 4. Systemically healthy individuals.
  • \. Residual alveolar ridge height ranging from 4 to 6 mm (measured by preoperative CBCT) 6. No previous surgical or radiation treatment involving the maxillary sinus.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Alazhar university , cairo, egypt

Cairo, Egypt

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
associate professor of oral medicine and periodontology

Study Record Dates

First Submitted

June 25, 2026

First Posted

July 1, 2026

Study Start

November 5, 2025

Primary Completion (Estimated)

November 10, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

July 1, 2026

Record last verified: 2026-06

Locations

EG(1)